Diabetes is a frequent complication seen in cystic fibrosis patients as they reach adulthood. Cystic fibrosis related diabetes (CFRD) is distinguished as a separate entity with features that include progressive loss of islet beta cell mass and insulin deficiency, as well as insulin resistance. Abnormalities in glucose tolerance may be detectable for many years prior to the development of overt ...

BACKGROUND Magnetic resonance imaging (MRI) has been shown to be a useful tool to evaluate the volume of the pancreas. There is currently no information about the size of the spleen in cystic fibrosis (CF) patients. PATIENTS AND METHODS We investigated 51 adult volunteers: 28 pancreatic insufficient CF patients [13 with CF-related diabetes (CFRD) and 15 non-diabetic] and 23 male non-CF patien...

Cystic fibrosis-related diabetes mellitus (CFRD) is the most frequent comorbidity in cystic fibrosis. Its clinical relevance is stressed by the association with increased mortality, and decreased pulmonary and nutritional status. An annual oral glucose tolerance test (OGTT) is recommended as a screening test for CFRD, but this is often not realised because of its time- and resource-consuming na...

Diabetes is a common and important complication of cystic fibrosis, an autosomal recessive genetic disease due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Cystic fibrosis-related diabetes (CFRD) is associated with profound detrimental effects on the disease course and mortality and is expected to increase in prevalence as the survival of patients with cy...

Abstract: The seepage control system of a high Concrete Face Rock-Fill Dam (CFRD) may have anti-seepage deficiencies during both construction and operation. In order to solve these, the three-dimensional Finite Element Method (FEM) model was built based on dam body filling, anti-seepage system, defect location and bedrock distribution. The seepage field simulation and computation were carried o...

OBJECTIVE While glucose tolerance abnormalities are common in cystic fibrosis (CF), impaired fasting glucose (IFG) has scarcely been explored. No studies have examined the relation between IFG and clinical status. RESEARCH DESIGN AND METHODS Data were retrieved from the University of Minnesota CF database on oral glucose tolerance tests (OGTTs) performed in 1996-2005. Subjects were identified...

Dam settlement monitoring is a crucial project in the safety management of concrete face rockfill dams (CFRD) over their whole life cycle. With development an automatic system, large amount data was collected. To precisely predict structural health dams, combined multiple points (MMP) model and machine learning has been developed. In this paper, based on physical factors CFRD, we comprehensivel...

Cystic Fibrosis Diabetes (CFRD) is the most common complication affecting approx. 40–50% of adults with cystic fibrosis (CF). Physical activity (PA) and exercise are recommended for management CF can also benefit blood glucose levels (BGL). Physiotherapists (PT) routinely counsel patients CFRD about taking regular PA supervise sessions. To assess PT knowledge understanding BGL whilst supervisin...

OBJECTIVE Diabetes is common in cystic fibrosis and increases the risk of death, yet the role of hyperglycemia remains unproven. An association between glycemia and mortality would provide compelling evidence to support glucose lowering in cystic fibrosis-related diabetes (CFRD). RESEARCH DESIGN AND METHODS Using the U.K. Cystic Fibrosis Registry, we analyzed longitudinal data from 2006 to 20...