OBJECTIVE To assess the efficacy and safety of vaginal misoprostol after a pretreatment with vaginal estradiol to facilitate the hysteroscopic surgery in postmenopausal women. METHODS In this observational comparative study, 35 control women (group A) did not receive any pharmacological treatment,26 women (group B) received 25 µg of vaginal estradiol daily for 14 days and 400 µg of vaginal mi...

sists mainly of collagen, hyaluronan, and proteoglycan. During gestation, it must close firmly to retain the fetus in the uterus. It undergoes ripening and dilatation at term, forming a parturient canal so that delivery can occur. During ripening, there are increases of collagen degradation in connective tissues, and proteoheparan sulfate, while decorin decreases. Inflammatory mediators, such a...

BACKGROUND Embryo transfer is a critical factor affecting the success of IVF-the ease of embryo transfer has a direct impact on the success rate. The aim of this study was to assess the value of cervical dilatation with hygroscopic cervical rods (Dilapan-S) in patients with difficult embryo transfer. METHODS Fifty-four patients undergoing IVF treatment, who either failed to conceive after pre...

BACKGROUND Although several randomized controlled trials (RCTs) have examined the effect of misoprostol prior to hysteroscopy for cervical dilatation, no solid conclusion has been reached. We therefore set out to perform a meta-analysis of RCTs. METHODS We searched MEDLINE, the ISI Web of Science and the Cochrane Library to identify RCTs comparing misoprostol versus placebo or control prior t...

BACKGROUND Various drugs have been tried to hasten cervical dilatation so that problems and hazards of prolonged labour both for the mother and fetus are minimised without increasing maternal or perinatal mortality and morbidity. AIMS AND OBJECTIVES To compare the effect of camylofin dihydrochloride with combination of valethemate bromide (epidosin) & hyoscine N butyl bromide (buscopan) on ce...

Cervical incompetence is characterized by painless dilatation of the incompetent cervix and results in miscarriages and preterm delivery during second trimester. We report a 25-year-old patient, gravid 2, para 1, at 11 weeks' gestation with the diagnosis of cervical incompetence, in whom transvaginal cerclage was not technically possible and laparoscopic cervical cerclage was performed successf...

A twin gestation invariably leads to a certain extent of cervical length shortening . If this reduction is also associated with gradual dilatation internal os and various biochemical , mechanical changes in matrix can lead mid trimester pregnancy loss or preterm labour. This case report on Dichorionic Diamniotic incompetence which rescue cerclage was performed along judicious use tocolysis vagi...