Results of previous studies have shown that the VX2 carcinoma in rabbits synthesizes large amounts of prostaglandin E2 (PGE2). PGE2 secreted by the tumor is rapidly metabolized and can be measured in plasma as the metabolite 13,14-dihydro-15-keto-PGE2 (PGE2-M). We have previously proposed that the hypercalcemia that occurs in rabbits bearing the VX2 carcinoma is due to excessive secretion of PG...

in order to determine the copper status and correlation between the ceruloplasmin and copper of serum and among the copper of serum, liver and kidney of slaughtered goats in shahrekord, blood, liver and kidney samples (10 gr) from 100 goats were gathered. the amounts of ceruloplasmin and copper of serum, liver and kidney were measured by sunderman - nomoto and shimadzu atomic absorption method,...

The present study was aimed at verifying whether serum L-fucose, total sialic acid (TSA) and ceruloplasmin can be used as prognostic indicators for type II diabetes mellitus, which will help in detecting complications of diabetes at an earlier stage. Thirty confirmed type II diabetic patients and 30 non-diabetic subjects were considered for the study. Serum L-fucose, total sialic acid and cerul...

Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed in the mammalian CNS. To better understand the role of ceruloplasmin in iron homeostasis in the CNS, we generated a ceruloplasmin gene-deficient (Cp(-/-)) mouse. Adult Cp(-/-) mice showed increase...

Ceruloplasmin and transferrin are proteins which play a potential role in the process of breast cancer development. These molecules contain Cu2+ (ceruloplasmin) or Fe3+ ions (transferrin) and thus constitute paramagnetic centers, which can be studied using electron paramagnetic resonance method. The aim of the study was to determine how paramagnetic centers in whole blood of breast cancer patie...

BACKGROUND Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage. This study presents data related to Hp phenotypes and ceruloplasmin ferroxidase activity in relation to iron store markers in patients with β-thalassemia major. METHODS Blood specimens were collected from 196 subjects (124 β-thalassemia major patients and 72...

AIM The aim of this study is to determine serum ceruloplasmin levels in cows with endometritis of varying degrees of severity and to establish whether or not there is a correlation between acute phase protein (APP) levels and biochemical parameters. MATERIAL AND METHODS The study was conducted with 100 Brown Swiss cows (3-8 years of age) on days 28-32 postpartum. Cows were divided into endome...

Ceruloplasmin is a copper-containing ferroxidase that is essential for normal iron homeostasis. Whereas ceruloplasmin in plasma is produced and secreted by hepatocytes, in the brain a glycosylphosphatidylinositol (GPI)-anchored form of ceruloplasmin is expressed on the surface of astrocytes. By using a cDNA cloning approach, we have now determined that the GPI-anchored form of ceruloplasmin is ...

Copper, a strong prooxidant, may play a role in atherogenesis. Serum Cu and caeruloplasmin levels have been suggested to be independent risk factors for coronary heart disease operating through oxidative modification of low density lipoprotein. Fifty cases of Acute Myocardial Iinfarction and fifty age and sex-matched controls were recruited. Copper and ceruloplasmin levels were estimated in con...