Cerebral hypoperfusion is associated with enhanced cognitive decline and increased risk of neuropsychiatric disorders. Erythropoietin (EPO) a neurotrophic factor known to improve function in preclinical clinical studies neurodegenerative psychiatric However, the application EPO limited due its erythropoietic activity that can adversely elevate hematocrit non-anemic populations. Carbamoylated er...

OBJECTIVE Recently, a concept of an individually targeted level of cerebral perfusion pressure that aims to restore impaired cerebral vasoreactivity has been advocated after traumatic brain injury. The relationship between cerebral perfusion pressure and pressure reactivity index normally is supposed to have a U-shape with its minimum interpreted as the value of "optimal" cerebral perfusion pre...

Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control su...

BACKGROUND Central elastic artery stiffness can increase vascular resistance and induce hypertrophic remodeling of cerebral arterioles and, in turn, may increase the risk of cerebral hypoperfusion. In this study, we examined whether central artery stiffness was directly associated with cerebral perfusion. METHODS Thirty-five adults (15 men and 20 women; 49 ± 7 years) were studied. Central art...

Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes, necessitating the adjunctive use of antegr...

This review summarizes evidence in humans for an association between hyperventilation (HV)-induced hypocapnia and a reduction in cerebral perfusion leading to syncope defined as transient loss of consciousness (TLOC). The cerebral vasculature is sensitive to changes in both the arterial carbon dioxide (PaCO2) and oxygen (PaO2) partial pressures so that hypercapnia/hypoxia increases and hypocapn...

Unilateral selective cerebral perfusion through right brachial artery is one of the cerebral protection methods for aortic arch repair. The purpose of this study is to determine whether cerebral perfusion through contra-lateral hemisphere is adequate or not. Seventeen consecutive patients underwent aortic arch repair using low flow antegrade selective cerebral perfusion (ASCP) through right bra...

BACKGROUND AND PURPOSE The purpose of this study was to evaluate the potential clinical value of arterial spin-labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) through comparison with dynamic susceptibility contrast (DSC) enhanced perfusion MRI. METHODS Pseudocontinuous ASL with 3-dimensional background-suppressed gradient and spin echo readout was applied with DSC perfusion MRI on ...

A method for monitoring cortical perfusion by laser Doppler flowmetry (LDF) in the neurointensive care unit is described. Out of 22 patients with head injuries, reliable and long term recordings were obtained in 16. Laser Doppler flowmetry registered changes in cortical microcirculatory flow in response to spontaneous waves of raised intracranial pressure, and to therapeutic manoeuvres that alt...

Starting with the inaugural issue, we would like the AORTA journal to feature a special section, “Poll the Editorial Board,” in which readers ask questions and the journal provides a poll of answers from the Editorial Board. In this way, we hope to assess the thought and practice patterns of the Editorial Board. The question for the first issue was: Which method of cerebral protection do you fa...