Background–The association of overweight/obesity with the incidence of cardiovascular diseases, especially stroke, has not been comprehensively examined in relatively lean populations in which stroke is more prevalent than coronary heart disease. Methods and Results–Pooled individual data from 16 Japanese cohorts comprising 45 235 participants ages 40 to 89 years without previous history of car...

BACKGROUND AND PURPOSE A traditional diet that is poor in animal products is thought to explain the high rate of stroke in Asian populations. The purpose of the present study was to examine the effect of a diet rich in animal protein, animal fat, and cholesterol on the risk of cerebral infarction mortality in a Japanese population. METHODS A prospective study of 3731 Japanese men and women ag...

Objective: The aim of this study was to explore if the single nucleotide polymorphism (SNP) IL-6 related susceptibility, severity neurological deficit and recurrence risk cerebral infarction (CI). Methods: Three hundred eighty-two patients with CI 385 healthy controls were selected for gene promotor region-174G /C, -572C/G, -597G/A by SNaPshot SNP typing. National Institute Health Stroke Scale ...

BACKGROUND Clinical and radiologic predictors of cerebral infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. METHODS We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (C...

BACKGROUND The association of overweight/obesity with the incidence of cardiovascular diseases, especially stroke, has not been comprehensively examined in relatively lean populations in which stroke is more prevalent than coronary heart disease. METHODS AND RESULTS Pooled individual data from 16 Japanese cohorts comprising 45 235 participants ages 40 to 89 years without previous history of c...

IMPORTANCE Emergency treatment options in myocardial infarction are guided by presence or absence of ST-elevations in electrocardiography. Occurrence and factors associated with ST-presentation in different population groups are however inadequately known. OBJECTIVE To determine likelihood and patient features associated with ST-elevations in myocardial infarction. DESIGN Nationwide registr...

INTRODUCTION AND OBJECTIVES To investigate cardiovascular risk profiles and their prognostic implications in patients with different subtypes of cerebral infarction. METHODS The study involved the retrospective analysis of data from a hospital stroke registry on 2704 consecutive CI patients who were admitted between 1986 and 2004. Of the 2704 strokes recorded, 770 were classified as thromboti...

Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ALOX5AP-SG13S114A/T (rs10507391), COX-2-765G/C (rs20417), and COX-1...