although the etiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function because the endothelium regulates vessel tone and synthesizes many pro- and anti-inflammatory factors. the aim of this study was to investigate the evidence involving the endothelium in the development of varicose vein disease. in addition, tissue remodeling was invest...

background & aims of the study: oxidative stress increases platelet-derived growth factor (pdgf) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. oxidative stress generates by dys-regulated redox balance between ros producing systems and antioxidant systems. also, curcumin (cur) as a main part of turmeric has anti- inflammatory, antioxidant, ant...

background: myocardial infarction is the main cause of death worldwide. angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. this study focused on improving myocardial function using endothelial cells (ecs) and mesenchymal stem cells (mscs) in a sheep animal model. methods: acute myocardia...

We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data su...

objective: endothelium is a selective and permeable membrane for transferring nutrients and vital components to arterial wall. endothelial damage might lead to altered biological function of endothelium and clinical consequences such as atherosclerosis. blood pressure pulse always exerts circumferential tension to the arterial wall. hence, such tension together with other loads, play important ...

Abstract The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis started near plaques in both AD mouse models and samples. However, endothelial cells express molecular signature of non-productive (NPA) accumulate, plaques, a tip cell marker IB4 reactive vascular a...

Malaria is one of the most serious of all tropical parasitic diseases: a severe and life-threatening form of which in humans is cerebral malaria, a complication that can occur in malaria caused by Plasmodium falciparum. This grave complication involves malarial infection of the red blood cells that accumulate within the very small capillaries that fl ow through the tissues of the brain. Even wh...

introduction: angiogenesis play an important role in many physiological processes (embryonic growth, tissue repair, etc) and also in pathological ones (diabetes, retinopathy, arthritis, tumor growth, etc). evaluation of endothelial cell growth and finally new vessel development in vivo is a complex and often difficult task. materials & methods: to address this issue an in vitro experimental ang...

Yakubu, Momoh A., and Charles W. Leffler. L-type voltage-dependent Ca2 channels in cerebral microvascular endothelial cells and ET-1 biosynthesis. Am J Physiol Cell Physiol 283: C1687–C1695, 2002. First published August 22, 2002; 10.1152/ajpcell.00071.2002.—We investigated the role of intracellular calcium concentration ([Ca2 ]i) in endothelin-1 (ET-1) production, the effects of potential vasos...