We measured cerebral blood flow using both the radioactive microsphere technique and the cerebral venous outflow technique in dogs anesthetized with chloralase. The effect of sympathetic stimulation on cerebral blood flow was observed during both normocapnia and prolonged hypercapnia using both blood flow techniques. The increase in blood flow with hypercapnia was the same with both methods. Du...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

BACKGROUND AND PURPOSE This study sought to determine the degree of agreement between asymmetries of neuropsychological functioning and nine methods of quantifying asymmetries of regional cerebral blood flow. METHODS The regional cerebral blood flow methods combined three markers of cerebral blood flow asymmetry (percent hemispheric difference, maximum percent probe-pair asymmetry, and number...

BACKGROUND AND PURPOSE Cerebral hypoperfusion has occasionally been reported during essential hypertension. We explored regional cerebral blood flow in a large series of neurologically asymptomatic hypertensive patients to determine relations among cerebral blood flow, concomitant main vascular risk factors, and the most common signs of end-organ damage. METHODS Regional cerebral blood flow w...

The left cerebral hemisphere of Mongolian gerbils was used to elucidate the mechanisms of brain edema which develop during cerebral ischemia and after restoration of cerebral blood flow following temporary ischemia. Water content was measured by the tissue-drying method. Sodium and potssium ion concentration was measured by flame photometry. Passage of 131I-albumin (RISA) from blood to the cere...

BACKGROUND AND PURPOSE Individualizing mean arterial blood pressure targets to a patient's cerebral blood flow autoregulatory range might prevent brain ischemia for patients undergoing cardiopulmonary bypass (CPB). This study compares the accuracy of real-time cerebral blood flow autoregulation monitoring using near-infrared spectroscopy with that of transcranial Doppler. METHODS Sixty adult ...

Objective(s): Multifunctional nanomedicine is the new generation of medicine, which is remarkably promising and associated with the minimum toxicity of targeted therapy. Distribution and transport of nanoparticles (NPs) in the blood flow are essential to the evaluation of delivery efficacy. Materials and Methods: In the present study, we initially designed a phantom based on Murray’s mini...