Drug Delivery In article number 2212210, Funan Liu, Hongjun Li, Zhen Gu, and co-workers present an oncolytic virus therapy that can target metastasis after systemic administration. Tumor cells have been pre-infected with serve as the delivery vehicle pathogenicity has eliminated by liquid nitrogen shock, but their metastasis-targeting ability is maintained integrity of cellular structure surfac...

Electronic pacemakers still face major shortcomings that are largely intrinsic to their hardware-based design. Radical improvements can potentially be generated by gene or cell therapy-based biological pacemakers. Our previous work identified adenoviral transfer of Hcn2 and SkM1, encoding a “funny current” skeletal fast sodium current, respectively, as potent combination induce short-term pacin...

P(MAA-g-EG) microparticles have been extensively investigated as carriers for oral delivery of proteins such as insulin. In this study, we investigated the effect of the molecular weight of the PEG tethered chains in the copolymer network and of the microparticle size on the transepithelial electrical resistance (TEER) and insulin epithelial permeability, using monolayers of human intestinal ep...

Cellular delivery is crucial for the discovery and development of novel drugs and probes. However, the efficient and reliable delivery of bioactive molecules into cells remains both challenging and limited in scope. Therefore, there is an emerging interest to develop conceptually innovative approaches to precisely deliver relevant biomolecules to a target site. With this in mind, Matile and co-...