Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...

a desmoplastic small round cell tumor is a malignant tumor of the abdominal and pelvic cavities. this tumor involves serosal surfaces such as the peritoneum, pleura, and scrotum. in this case report a 28-year old male presented with a desmoplastic small round cell tumor located in the abdomen along with urological symptoms. when the diagnosis was completed, the patient’s tumor had metastasized ...

Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce pe...

Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of ...

The granulosa cell tumor is the most common malignant functioning tumor of the ovary. When functional, granulosa tumor almost always are estrogenic although rare tumors are androgenic. Progesterone producing by these tumors has only been reported twice. We report a case of granulosa cell tumor in a 7 years old girl with precocious puberty who represent the first case of progesterone producing b...

Due to the properties of tumor cell, the tumor establishes itself in the organ and grows there, so there is a competition between the tumor cells and host cell (normal cells) for nutrients. Evidences show that high dietary phosphorus increases the rate of protein synthesis and thus the cell number. So, other than oxygen, sulfur, the important element that both tumor cells and normal cells need ...

background recent studies revealed that tumor-associated macrophages (tams) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. signal transducer and activator of transcription 3 (stat3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activa...

objective: micrornas (mirnas) are a new class of non-coding rnas involved in regulating various biological processes including proliferation, differentiation, and apoptosis, among others. alterations in mirna expression are reported in several human cancers, which suggests their potential roles in tumor initiation and progression. members of the mir-302 cluster are highly expressed in embryonic...

Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...