Supported lipid bilayers (SLBs) are one of the most common cell-membrane model systems to study cell-cell interactions. Nickel-chelating lipids frequently used functionalize SLB with polyhistidine-tagged ligands. We show here that these by themselves can induce calcium signaling in T cells, also when having protein ligands on SLB. This is important avoid “false” events cell studies SLBs, but be...

Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin signaling pathway.Materials and Methods: Eca109 cells were classified into 5 groups: Control group, H2O2 group, Propofol + H2O2 group, Dkk1 (Dickkopf-1, Wnt/β-catenin pathway antagonist) + H2O2 group...

background: this research studies the effects of activation and inhibition of wnt3a signaling pathway in buffalo (bubalus bubalis) embryonic stem (es) cell-like cells. materials and methods: to carry on this experimental study, the effects of activation and inhibition of wnt3a signaling in buffalo es cell-like cells were examined using bio (0.5 mm) combined with wnt3a (200 ng/ml), as an activat...

introduction: g-proteins have an important role in the cell signaling of numerous receptors. the situation of g-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. here, the changes in the expression of g-protein subunits (gαi, gαs and gβ) were evaluated in hyperglycemic situation of pc12 cells as a cellular model...

neurological inflammatory diseases are developing rapidly. different factors involved in the pathogenesis of these diseases. in this article, we discuss some of the mechanisms are dealt with. an aberrant procedure of beta-amyloid precursor protein (bapp) to form neurotoxic beta-amyloid peptides and an accumulated insoluble polymer of beta –amyloid (ba) that forms the senile plaque. the above pr...

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

Abstract Successful initiation of the B-cell receptor (BCR) signaling, and subsequent antigen-encounter in germinal centers are both marked by sharp increases CD25 surface-expression. Likewise, oncogenic signaling leukemia (B-ALL) lymphoma induces CD25-surface expression. While is known as an IL2-receptor chain on T- NK-cells, significance its expression B-cells was unclear. We discovered that,...

Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault prot...