The v-SNARE TI-VAMP (VAMP7) mediates exocytosis during neuritogenesis, phagocytosis and lysosomal secretion. It localizes to endosomes and lysosomes but also to the trans-Golgi network. Here we show that depletion of TI-VAMP enhances the endocytosis of activated EGF receptor (EGFR) without affecting constitutive endocytosis of EGFR, or transferrin uptake. This increased EGFR internalization is ...

BACKGROUND Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Currently there are no known risk factors for CNS involvement. CASE PRESENTATION We describe a clinically staged low-risk CLL case that presented with symptomatic CNS involvement an...

objective: prostate cancer is one of the most common cancer in the developed countries. most of cancer deaths are due to development of metastasis. hence, prevention of metastasis is critical. silibinin is a flavonoid component that inhibits cell proliferation and causes cell death of human prostate cancer. in this study, the expression of cd82 gene in pc-3 cells treated with escalating concent...

Cell-cell adhesion is mediated by interaction of a number of protein complexes residing on the cell plasma membranes. Disruption of these complexes affects structural and functional integrity of tissues. It has been hypothesized that a membrane protein tetraspanin CD82, a known metastasis suppressor, may play a role in regulating cell adhesion. Two proteins of interest (PG and Dsg2) have been f...

T-cell precursors that undergo productive rearrangements at the T-cell receptor (TCR) b locus are selected for proliferation and further maturation, before TCRa expression, by signaling through a pre–TCR composed of the TCRb chain paired with a pre–TCRa (pTa) chain. Such a critical developmental checkpoint, known as b-selection, results in progression from CD42 CD82 double negative (DN) to CD41...

In Focus • THE JOURNAL OF CELL BIOLOGY ␤-Catenin gets an honorable discharge B eta-catenin binds E-cadherin to facilitate the formation of inter-cellular adhesions, but it's also a central component of the Wnt signaling pathway that controls cell proliferation and differentiation (1). Activation of the Wnt pathway stabilizes ␤-catenin, enabling it to translocate into the nucleus and pair up wit...

Conventional therapies still remain less effective for metastasis of lung cancer, thus leading to a poor prognosis for this disorder. Although the processes involved in metastasis have not yet been clearly elucidated, our previous studies have shown that higher expression levels of MRP-1/CD9 and KAI1/CD82 in cancer cells are significantly correlated with less metastatic potency. To determine wh...

BACKGROUND Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the NM23-H1, NDRG1, E-cadherin, RHOGDI2, CD82/KAI1, MKK4, and AKAP12 metastasis suppressor proteins in BCCs. METHODS A total of 96 BCC and 10 normal skin samples were included for ...

T-cell activation is initiated by the concerted engagement of the T-cell receptor and different co-stimulatory molecules, and requires cytoskeleton-dependent membrane dynamics. Here, we have studied the relationships between tetraspanins, cytoskeleton and raft microdomains, and their relevance in T-cell signaling. Localization studies and density-gradient flotation experiments indicate that par...