نتایج جستجو برای: cd80

تعداد نتایج: 2396  

Journal: :Journal of immunology 1998
G Boulougouris J D McLeod Y I Patel C N Ellwood L S Walker D M Sansom

CD28 and CTLA-4 are related receptors that differentially regulate T cell activation. Despite the fact that they bind the same ligands, CD28 is a classical costimulator enhancing proliferation whereas CTLA-4 appears to perform negative regulatory functions. In this study, we have utilized the natural ligand for CD28 and CTLA-4 (CD80) to determine under what circumstances positive and negative e...

Journal: :Cancer immunology research 2014
Samuel T Haile Lucas A Horn Suzanne Ostrand-Rosenberg

Tumor cells use various methods of immunosuppression to overcome antitumor immunity. One such method is that of programmed death ligand-1 (PD-L1 or B7-H1), which upon binding its receptor PD-1 on T cells triggers apoptotic death of the activated T cells. Overexpression of the costimulatory molecule CD80 on PD-L1(+) tumor cells, or inclusion of a soluble form of CD80 (CD80-Fc), maintains the act...

Journal: :Infection and immunity 2001
M Takahashi M Takahashi F Shinohara H Takada H Rikiishi

To investigate the mechanisms underlying superantigen (SAg) stimulation, we analyzed the effect of SAg on monocyte responses with or without lipopolysaccharide (LPS). Addition of gamma interferon (IFN-gamma) to unstimulated cultures induced a marked increase in the number of CD80(+) monocytes, which was inhibited by LPS through the action of interleukin-10. However, CD80(+) monocytes began to i...

Journal: :Journal of immunology 2012
Zhenghai Xu Veronica Juan Alexander Ivanov Zhiyuan Ma Dixie Polakoff David B Powers Robert B Dubridge Keith Wilson Yoshiko Akamatsu

CTLA4-Ig is an Fc fusion protein containing the extracellular domain of CTLA-4, a receptor known to deliver a negative signal to T cells. CTLA4-Ig modulates T cell costimulatory signals by blocking the CD80 and CD86 ligands from binding to CD28, which delivers a positive T cell costimulatory signal. To engineer CTLA4-Ig variants with altered binding affinity to CD80 and CD86, we employed a high...

Journal: :Science translational medicine 2014
Aline Bozec Mario M Zaiss Rosebeth Kagwiria Reinhard Voll Manfred Rauh Zhu Chen Sandra Mueller-Schmucker Richard A Kroczek Lucie Heinzerling Muriel Moser Andrew L Mellor Jean-Pierre David Georg Schett

Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism of bone resorption by the adaptive immune system. CD80/86, a pair of molecules expressed by antigen-presenting cells and involved in T cell co...

Journal: :Journal of Immunology 2021

Abstract Foxp3-expressing CD4+CD25+ regulatory T cells (Tregs) are engaged in the maintenance of immunological self-tolerance and homeostasis. They constitutively highly express immune checkpoint receptor CTLA-4, whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism Treg-mediated suppression, CTLA-4 downregulates expression CD80/CD86 costimulatory ligands on ant...

Journal: :Blood 2011
Shunsuke Kanada Chiharu Nishiyama Nobuhiro Nakano Ryuyo Suzuki Keiko Maeda Mutsuko Hara Nao Kitamura Hideoki Ogawa Ko Okumura

In this study, we investigated the role of a transcription factor, PU.1, in the regulation of CD80 and CD86 expression in dendritic cells (DCs). A chromatin immunoprecipitation assay revealed that PU.1 is constitutively bound to the CD80 and CD86 promoters in bone marrow-derived DCs. In addition, co-expression of PU.1 resulted in the transactivation of the CD80 and CD86 promoters in a reporter ...

Journal: :The Journal of infectious diseases 2007
David van Duin Heather G Allore Subhasis Mohanty Sandra Ginter Frances K Newman Robert B Belshe Ruslan Medzhitov Albert C Shaw

BACKGROUND Innate immunity, including Toll-like receptor (TLR)-mediated expression of the B7 costimulatory molecules CD80 and CD86, is critical for vaccine immunity. We examined whether CD80 and CD86 expression vary with aging and predict response to the trivalent inactivated influenza vaccine. METHODS One hundred sixty-two subjects between 21 and 30 years of age (the young group) or > or =65...

Journal: :Journal of immunology 1998
C S Subauste R de Waal Malefyt F Fuh

The costimulatory ligands CD80 and CD86 play a crucial role in the initiation and maintenance of an immune response. We demonstrate that whereas infection of human monocytes with viable tachyzoites of Toxoplasma gondii resulted in rapid induction of expression of CD80 and up-regulation of expression of CD86, incubation with killed organisms failed to alter the levels of expression of these cost...

2015
Catherine Olesch Weixiao Sha Carlo Angioni Lisa Katharina Sha Elias Açaf Paola Patrignani Per-Johan Jakobsson Heinfried H. Radeke Sabine Grösch Gerd Geisslinger Andreas von Knethen Andreas Weigert Bernhard Brüne

Prostaglandin E2 (PGE2) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated immunity. A new model of breast tumor spheroid killing by human PBMCs was developed. In this model...

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