نتایج جستجو برای: cd8 cd28

تعداد نتایج: 42691  

Journal: :Journal of immunology 2005
Lauren I Richie Ehrlich Kouetsu Ogasawara Jessica A Hamerman Rayna Takaki Alessandra Zingoni James P Allison Lewis L Lanier

CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ alphabeta-TCR+ T cells, and gammadelta-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulatin...

Journal: :Blood 2002
Young-June Kim Randy R Brutkiewicz Hal E Broxmeyer

The CD28(-) subset of CD8(+) T cells is associated with cytotoxic T lymphocyte (CTL) effector function. We investigated a potential role for 4-1BB, a costimulatory molecule structurally related to members of the tumor necrosis factor (TNF) receptor family, in the generation and functional activation of CD28(-) CTLs by using human cord blood (CB) cells composed exclusively of naive CD8(+) T cell...

Journal: :Nephrology Dialysis Transplantation 2023

Abstract Background and Aims Hemodiafiltration (HDF) is characterized by enhanced clearance of middle molecular weight toxins therefore, it considered superior to hemodialysis (HD), especially in higher hemofiltration volumes. Although proinflammatory cytokines are lower HDF, its impact on immune phenotype has not been studied, so far. In this study we compared the lymphocytes’ senescent betwee...

Journal: :Journal of immunology 1998
A Anumanthan A Bensussan L Boumsell A D Christ R S Blumberg S D Voss A T Patel M J Robertson L M Nadler G J Freeman

Expression of the BY55 protein has been shown to be tightly associated with NK and CD8+ T lymphocytes with cytolytic effector activity. To determine the function of this protein, we molecularly cloned BY55 cDNA. The cDNA sequence predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to killer inhibitory receptor...

2016
Hiroshi Ishii Saori Matsuoka Takushi Nomura Midori Nakamura Teiichiro Shiino Yuko Sato Naoko Iwata-Yoshikawa Hideki Hasegawa Kazuta Mizuta Hiromi Sakawaki Tomoyuki Miura Yoshio Koyanagi Taeko K. Naruse Akinori Kimura Tetsuro Matano

Virus-specific CD8(+) T cells exert strong suppressive pressure on human/simian immunodeficiency virus (HIV/SIV) replication. These responses have been intensively examined in peripheral blood mononuclear cells (PBMCs) but not fully analyzed in lymph nodes (LNs), where interaction between CD8(+) T cells and HIV/SIV-infected cells occurs. Here, we investigated target antigen specificity of CD8(+...

Journal: :Journal of leukocyte biology 2008
Rita Simone Anna Zicca Daniele Saverino

Aging is commonly associated with immune deficiency and dysregulation. The aging of the immune system involves a progressive reduction in naïve T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. We have investigated frequency, phenotype, and function of CD3+CD8+CD28(-)CD25+ T cells in healthy volunteers over a wide age range. We demonstrate t...

2004
Yang Bian Shin-ichiro Hiraoka Michio Tomura Xu-Yu Zhou Yumi Yashiro-Ohtani Yoshiko Mori Jun Shimizu Shiro Ono Kyriaki Dunussi-Joannopoulos Stanley Wolf Hiromi Fujiwara

The B7/CD28 costimulatory pathway plays a critical role in T cell activation including Th1/Th2 differentiation. However, little is known about whether CD28 costimulation favors polarization of either Th1 and Th2 or both. Here, we show a critical role of the natural ligands for CD28 molecules (B7.2–Ig or B7.1–Ig fusion proteins), particularly in the induction of type 2 T cell polarization. Upon ...

2009
Stanley T. Parish Jennifer E. Wu Rita B. Effros

Expanded populations of CD8 T lymphocytes lacking CD28 expression are associated with a variety of deleterious clinical outcomes, including early mortality in the elderly, more rapid progression to AIDS, cardiovascular disease, and enhanced tumor cell growth. In cell culture, irreversible loss of CD28 expression correlates with increased production of TNFas CD8 T cells are driven to the nonprol...

2013
Nicolás A. Giraldo Natalia I. Bolaños Adriana Cuellar Nubia Roa Zulma Cucunubá Fernando Rosas Víctor Velasco Concepción J. Puerta John M. González

BACKGROUND Chronic persistent infections have been associated with T lymphocytes functional impairment. The aim of this study was to compare the activation status, the proliferative potential and the expression of CD28 and CD3ζ chain on T lymphocytes between chronic chagasic patients and uninfected controls. METHODOLOGY/PRINCIPAL FINDINGS Forty-two chronic chagasic patients, 28 healthy indivi...

Journal: :International immunology 2005
Yang Bian Shin-Ichiro Hiraoka Michio Tomura Xu-Yu Zhou Yumi Yashiro-Ohtani Yoshiko Mori Jun Shimizu Shiro Ono Kyriaki Dunussi-Joannopoulos Stanley Wolf Hiromi Fujiwara

The B7/CD28 costimulatory pathway plays a critical role in T cell activation including Th1/Th2 differentiation. However, little is known about whether CD28 costimulation favors polarization of either Th1 and Th2 or both. Here, we show a critical role of the natural ligands for CD28 molecules (B7.2-Ig or B7.1-Ig fusion proteins), particularly in the induction of type 2 T cell polarization. Upon ...

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