نتایج جستجو برای: cd44 v3
تعداد نتایج: 12027 فیلتر نتایج به سال:
UNLABELLED Antibodies (Abs) specific for the V3 loop of the HIV-1 gp120 envelope neutralize most tier 1 and many tier 2 viruses and are present in essentially all HIV-infected individuals as well as immunized humans and animals. Vaccine-induced V3 Abs are associated with reduced HIV infection rates in humans and affect the nature of transmitted viruses in infected vaccinees, despite the fact th...
The third variable region (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope gp120 subunit participates in determination of viral infection coreceptor tropism and host humoral immune responses. Positive charge of the V3 plays a key role in determining viral coreceptor tropism. Here, we examined by bioinformatics, experimental, and protein modelling approaches whether the net posit...
The V3 epitope is a known target for HIV-1 neutralizing antibodies (NAbs), and V3-scaffold fusion proteins used as boosting immunogens after gp120 DNA priming were previously shown to induce NAbs in rabbits. Here, we evaluated whether the breadth and potency of the NAb response could be improved when boosted with rationally designed V3-scaffold immunogens. Rabbits were primed with codon-optimiz...
Background/Aim: We have tested whether the anticancer peptide, PNC-27, that kills cancer cells but not normal by binding to cell membrane HDM-2 forming pores, CD44+ colon stem cells. Materials and Methods: Flow cytometry determined CD44 expression on six-colon lines one line (CCD-18Co). MTT, LDH release, annexin V caspase 3 assays were used assess PNC-27-induced death. Bioluminescence imaging m...
CD44 is a transmembrane glycoprotein, the variant isoforms of which are coded for by alternative splicing, with the most prolific isoform being CD44 standard. CD44 is found in a wide variety of tissues including the central nervous system, lung, epidermis, liver, and pancreas, whereas variant isoforms of CD44 (CD44v) appear to have a much more restricted distribution. Variants of CD44 are expre...
Purpose of the study. Determine content cancer stem cells (CSCs) in tumor tissue (TT) and perifocal tissues (PT) muscle-non-invasive bladder cancer. Materials methods. We’ve examined fragments TT PT 7 (NMIBC) after surgical intervention – transurethral resection urinary (TUR). In samples that were used to obtain cell suspension using BD Medimachine apparatus (BD, USA) was treated with monoclona...
Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton.
CD44 is a widely expressed integral membrane glycoprotein that serves as a specific adhesion receptor for the extracellular matrix glycosaminoglycan hyaluronan. CD44 participates in a variety of physiological and pathological processes through its role in cell adhesion. Under appropriate conditions, the ectodomain of CD44 is proteolytically removed from the cell surface. In this study we show t...
Background and purpose: Smoking increases the incidence and severity of periodontal disease. Elevation in the level of salivary soluble CD44 is considered as a diagnostic marker in some smoking-induced disorders such as periodontal disease. This study evaluated the salivary soluble CD44 level in smokers and non-smokers with and without moderate chronic periodontitis, before and one month after ...
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