نتایج جستجو برای: cd226
تعداد نتایج: 208 فیلتر نتایج به سال:
Abstract Background Breast cancer is one of the most frequently diagnosed cancers among women worldwide. Alterations in tumor microenvironment (TME) have been increasingly recognized as key development and progression breast recent years. To deeply comprehend gene expression profiling TME identify immunological targets, well determine relationship between different prognoses highly critical. Me...
Background High expression of CD155 (poliovirus receptor, PVR) is associated with a poor prognosis lung adenocarcinoma (LUAD) and triple-negative breast cancer (TNBC) patients. When overexpressed, this molecule inhibits the antitumor function NK cytotoxic T cells through binding to its inhibitory co-receptors TIGIT CD96, downregulation stimulatory CD226 (DNAM-1). However, exact mechanism overex...
Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on the surface of cancer cells, endowing them with the capacity to activate potent...
Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating and inhibitory signals results in increased susceptibility to infection or the induction of autoimmunity. Similar to the well-characterized CD28/CTLA-4 costimulatory pathway, a newly emerging pathway consisting of CD226 and T cell Ig and ITIM domain (TIGIT) has been as...
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