BACKGROUND Women treated for breast cancer have an increased risk for developing metachronous contralateral breast cancer (CBC). Patient perception of this risk is often overestimated and has been found to contribute to the decision to undergo contralateral prophylactic mastectomy. An individual's risk is dependent on both patient and tumor characteristics. This review examines and summarizes t...

The aim of the present study was to investigate the therapeutic outcome of early-stage breast cancer (pT1aN0M0) and to identify prognostic factors for secondary primary contralateral breast cancer (CBC). A total of 85 patients with mammary carcinomas were included. All patients had undergone breast surgery and adjuvant treatment between January 2001 and December 2008 at the Central Hospital of ...

Compound banmao capsule (CBC) is a traditional Chinese medicinal formula composed of extracts from 11 organisms. The present study investigated the mechanism of CBC on the biological behavior of human leukemia cell lines using seropharmacological methods. CBC-containing rat serum was prepared by intragastrical administration of CBC to rats. The proliferation of human leukemia HL60 and K562 cell...

Identifying influential spreaders in complex networks has a significant impact on understanding and control of spreading process in networks. In this paper, we introduce a new centrality index to identify influential spreaders in a network based on the community structure of the network. The community-based centrality (CbC) considers both the number and sizes of communities that are directly li...

Multivariate radiation injury estimation algorithms were formulated for estimating severe hematopoietic acute radiation syndrome (H-ARS) injury (i.e., response category three or RC3) in a rhesus monkey total-body irradiation (TBI) model. Classical CBC and serum chemistry blood parameters were examined prior to irradiation (d 0) and on d 7, 10, 14, 21, and 25 after irradiation involving 24 nonhu...

A Credit-Based Controller (CBC), which has a provision for cell tagging, is proposed for usage parameter control (UPC). Similar in concept to the leaky bucket, the CBC has a credit counter and a data buuer. Credits are accumulated at a rate initiated from the network (equivalent to the sustainable cell rate), and depleted at a rate pertaining to the network traac load. A source has the prerogat...

OBJECTIVES The current use of metronidazole as an anti-amoebic agent causes significant side-effects. The purpose of this study was to identify alternative compounds with which to treat amoebiasis. METHODS We tested the effects of cyclopropyl (CPC) and cyclobutyl (CBC) carbinols on the survival of Entamoeba histolytica trophozoites and on the enzymatic activities of E. histolytica alcohol deh...

At CRYPTO 2015, Minaud and Seurin introduced and studied the iterated random permutation problem, which is to distinguish the r-th iterate of a random permutation from a random permutation. In this paper, we study the closely related iterated random function problem, and prove the first almost-tight bound in the adaptive setting. More specifically, we prove that the advantage to distinguish the...

In eukaryotes the majority of mRNAs have an m(7)G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism. The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation, and U snRNA export. As little is known about how nuclear CBC mediates the effects of ...