Reserpine-induced catalepsy is an animal model used to mimic the behavioural symptoms of Parkinson’s disease (PD) in experimental animals. The present study was designed to investigate the effect of aqueous and hydro-ethanolic extracts of Sida cordifolia (AESC and EESC respectively), in reserpine-induced orofacial dyskinesia and catalepsy along with lipid peroxidation evaluated by the levels of...

Reserpine-induced catalepsy is a widely accepted animal model of Parkinson's disease. In the present study reserpine (2.5 mg/kg, ip) 20 hr and alpha-mehyl-para-tyrosine (AMPT; 200 mg/kg, ip), one hour before the experiment induced significant catalepsy in rats as assessed by bar test. There was a significant increase in the time spent on the bar in bar test as compared to the control untreated ...

The enzyme phosphodiesterase 10A (PDE10A) regulates the activity of striatal, medium spiny neurons (MSNs), which are divided into a behaviorally stimulating, Gs-coupled D1 receptor-expressing "direct" pathway and a behaviorally suppressant, Gi-coupled D2 receptor-expressing "indirect" pathway. Activating both pathways, PDE10A inhibitors (PDE10AIs) combine functional characteristics of D2 antago...

The aim of the present study was to investigate the effect of ellagic acid on haloperidol-induced orofacial dyskinesia and catalepsy in Wistar male albino rats and to explore the possible underlying mechanisms for these effects. Haloperidol (1 mg/kg, ip) was administered on 21 successive days to induce orofacial dyskinesia in rats. Ellagic acid (10, 20 and 40 mg/kg, po) was administered for 21 ...

BACKGROUND AND THE PURPOSE OF THE STUDY The available literatures show that 5-HT(1A) receptors are widely distributed throughout the basal ganglia, and their activation facilitate dopamine release. Neuroleptic drugs such as haloperidol induce Parkinson-like syndrome through blocking brain D(2) receptors. This study aimed to investigate effect of buspirone, a partial agonist of 5HT(1A) receptor,...

The striatum and the nucleus accumbens are the main input structures of the basal ganglia (BG). They contribute differently to motor behavior controlled by the BG in rats, e.g., stereo-typed behavior, catalepsy, and locomotion. Whereas the striatum is predominantly involved in the control of sniffing behavior and catalepsy, the nucleus accumbens contributes to control of locomotion. To test whe...

Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective loss of dopamine neurons of the substantia nigra pars compacta. The present study is carried out to investigate the effect of acute and chronic administration of aqueous extract of Lawsonia inermis Linn. leaves on haloperidol induced catalepsy in albino mice which is a useful animal model for screening drugs for ...

The extremely slow return movements observed in stick insects (phasmids) after imposed changes in posture are termed catalepsy. In the literature, catalepsy is treated as a behavioural component of the twig mimesis observed in walking stick insects. It is produced by the high gain of the velocity-sensitive component of the relevant joint control systems and by the non-linear dependency of its t...