Background: The detrimental effects of persistent stimulation with hCG were investigated in rat Leydig cells in vitro. Materials and Methods: Oxidative stress parameters such as lipid peroxidation, Reactive oxygen species(ROS), Total antioxidant capcity (TAC) and activities of antioxidant enzymes were assessed in the treated cells. Apoptosis amongest the trearted cells were detected by in situ ...

Sedum middendorffianum Maxim (SMM) is a Korean endemic plant belonging to the Crassulaceae family. This study aimed investigate antitumor effects of SMM extract on human ovarian cancer cells. Among five plants grown in Korea, showed most potent cytotoxicity cells and had little effect normal surface epithelial Furthermore, we revealed that dose-dependently induced apoptosis A2780 SKOV3 The mark...

Background: Using natural compounds with low toxicity on normal cells and high efficacy on malignant cells is highly appreciated for treatment of colorectal cancer (CRC). In the present study, the effect of fish-oil derived eicosapentaenoic acid (EPA) on the cell number, cell proliferation rate and caspase-3 enzyme activity in LS174T human colorectal cancer cell line was investigated. Methods:...

background: gold nanoparticles (gnps) are used in imaging and molecular diagnostic applications. as the development of a novel approach in the green synthesis of metal nanoparticles is of great importance and a necessity, a simple and safe method for the synthesis of gnps using plant extracts of zataria multiflora leaves was applied in this study and the results on gnps’ anticancer activity aga...

Epidemiological studies have evidenced that natural dietary products can prevent or manage gastric cancer. Neptunia oleracea, an aquatic vegetable and edible plant, has been reported to anti-cancer properties. In this study, N. oleracea extract’s suppression of cancer cells was investigated on in vitro experimental model. We found ethyl acetate (EtOAc) extract inhibited cell proliferation at IC...

Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer effect of an ethanol extract MC fruit, Kuguacin-J (K-J), isolated compound leaves and cisplatin, either alone or combination on healthy MCF-10A mammary cells co...

background and objectives: achillea is an ancient medicinal herb. the genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. there are also several reports in iranian traditional medicine (itm) texts about its anti-tumor effect. the cytotoxic activity of the methanol extract of achillea vermicula...

We examined the influence of sepsis on the expression and activity of the calpain and caspase systems in skeletal muscle. Sepsis was induced in rats by cecal ligation and puncture (CLP). Control rats were sham operated. Calpain activity was determined by measuring the calcium-dependent hydrolysis of casein and by casein zymography. The activity of the endogenous calpain inhibitor calpastatin wa...

Initiation of apopotosis requires the conversion of procaspases to mature caspases. Here we show that oligomerization of pro-caspases is sufficient to induce proteolytic generation of mature caspase subunits and activation of their cell death activity. Deletion of the protein interaction motif DED from pro-caspase-8 greatly suppresses its apoptotic activity. Cell death activity can be restored ...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...