Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors. Recently, functionalized indeno[1,2-b]indoles have been revealed to have high potency against human cancer cell lines such as MCF-7 breast carc...

κ-casein is a glycosilated protein belonging to a family of phosphoproteins (αs1,β, αs2,κ) that represents the major protein component in mammalian milk. κ-casein plays an essential role in the case of micelle stabilization, determining the size and the specific biological function. In the present study, we report the characterization of the partial sequence of κ-casein promoter region in the I...

κ-casein is a glycosilated protein belonging to a family of phosphoproteins (αs1,β, αs2,κ) that represents the major protein component in mammalian milk. κ-casein plays an essential role in the case of micelle stabilization, determining the size and the specific biological function. In the present study, we report the characterization of the partial sequence of κ-casein promoter region in the I...

the purpose of this study was to investigate the effect of feeding dietary soy protein and soy protein supplemented with methionine on lipids and lipoproteins content of blood in wistar rats. sixteen male and 16 female wistar rats with the initial live weight of 116 ± 6.3 and 115.8 ± 6.8 grams respectively, were fed by the isocaloric and isonitrogenous diets containing casein (20%), soy protein...

Milk is composed of water, proteins, lipids, lactose, vit-amins, and minerals. More than 80% most mam-mals’ milk proteins are con-stituted by caseins. Casein a group they sub-divided into αs1-, αs2-, β- -casein families. Among these ca-sein families, -casein the second abundant pro-tein. Different mutations in cow gene led to 12 genetic variants common A1 A2. The A2 differ only at amino acid ...

Casein micelles with bound lactoferrin or lysozyme were fractionated into sizes ranging in radius from ∼50 to 100 nm. The κ-casein content decreased markedly and the αS-casein/β-casein content increased slightly as micelle size increased. For lactoferrin, higher levels were bound to smaller micelles. The lactoferrin/κ-casein ratio was constant for all micelle sizes, whereas the lactoferrin/αS-c...

Experiments were conducted to clarify the relationship between dietary protein level and plasma homocysteine concentration in rats. Male Wistar rats were fed diets differing in casein level from 5 to 50% for 14 d (Expt. 1). Plasma total homocysteine concentration was positively correlated with dietary casein level in the range of 5 to 10% but inversely correlated with dietary casein level in th...

Mammalian milk is a complex fluid mixture of various proteins, minerals, and lipids, which play an important role in providing nutrition and immunity to the newborn. Casein proteins, which form about 80% of the bovine milk proteins, form large colloidal particles with calcium phosphate to form casein micelles, which for many years have been an important subject of interest. Casein micelles are ...

In this study, protein and salt distributions in the milk of 48 Holstein-Friesian cows were studied. Gross composition samples variation between individual was line with expectation. However, mineralisation casein fraction, expressed mmol protein-associated calcium per 10 g casein, differed >2-fold samples. Reasons for are unknown could not be correlated to and/or genetic variants caseins. Furt...