objective (s): there is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. gamma oryzanol (go) is one of the major bioactive components in rice bran has been considered to function as an antioxidant. the present study was carried out to evaluate the antioxidant activity of gamma oryzanol in vitro and its effica...

PURPOSE Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose of this study was to determine whether treatment with the antioxidant ubiquinol improves muscle mass, cardiac function, and behavioral measures...

The aim of the present study was to investigate the chemical composition and antioxidant activity of Satureja montana essential oil of Romanian origin (S. montana EO). The essential oil was obtained by hydrodistillation from dried aerial parts of cultivated plants in northeastern Romania. The chemical composition of S. montana EO was analysed by GC and GC-MS. The main compounds were carvacrol (...

BACKGROUND Individual biomarkers of inflammation, endothelial dysfunction and oxidative stress have been associated with cognitive impairment. This study explored whether a combination of biomarkers could prospectively identify those who developed cognitive decline. METHODS Biomarkers were obtained during the baseline examination of the Beaver Dam Eye Study (1988-90), and cognitive status was...

The inflammatory etiology of atherosclerosis has prompted a search for biomarkers of inflammation that predict risk for coronary artery disease and its sequelae. Within the acute coronary syndromes (ACS), inflammatory biomarkers may provide independent information regarding pathophysiology, prognosis, and optimal therapeutic strategies. On the basis of the hypothesis that different pathophysiol...

PRO--PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. CON--Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneo...

BACKGROUND Mitochondria are the main source of reactive oxygen species (ROS). Human mitochondrial haplogroups are linked to differences in ROS production and oxidative-stress induced inflammation that may influence disease pathogenesis, including coronary artery disease (CAD). We previously showed that traffic-related air pollutants were associated with biomarkers of systemic inflammation in a ...

The prevalence of diabetes is increasing and has already reached pandemic proportions. Diabetes is a well-known risk factor for chronic kidney disease. Diabetic kidney disease (DKD) occurs in up to 40% of people with type 1 or 2 diabetes and is nowadays the leading cause of end-stage renal disease (ESRD). Among several factors involved in the development and progression of DKD are also inflamma...

platelet aggregation beta amyloid main causes inflammation of neurons in alzheimer’s disease. in fact, creating this inflammation due to inappropriate actions in blood brain barrier (bbb) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. the only thing that can be done to prevent and reduce pro-inflammatory factors such as cytokines ...

nigella sativa (ns) ( ranunculaceae ) used as a protective and therapeutic traditional medicine. this study evaluates the effect of ns on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. fifty male wistar rats were divided into five groups: (1) control; (2) lipopolysaccharide (lps), 1 mg/kg/day; (3) lps + ns (hydroalcohol...