Objective: Crocinisa saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...

Xenon is one of noble gases and has been recognized as an anesthetic for more than 50 years. Xenon possesses many of the characteristics of an ideal anesthetic, but it is not widely applied in clinical practice mainly because of its high cost. In recent years, numerous studies have demonstrated that xenon as an anesthetic can exert neuroprotective and cardioprotective effects in different model...

Novel derivatives of the apple-derived flavonoid phloridzin have been found to be potent antioxidants in vitro [I] . The antioxidant action of oestrogens such as 17 P-oestradiol may contribute to their cardioprotective effects [2]. Phloretin the aglycone form of phloridzin has been reported to be oestrogenic [3] and its 3-hydroxy derivative may have enhanced weak oestrogen activity that could e...

DOI: 10.5935/abc.20180011 The possibility of limiting ischemic myocardial injury has been a major focus of cardiovascular research over 4 decades and literally thousands of interventions have been tested in this direction.1 Unfortunately, this has been a long, unsolved saga, and, apart from reperfusion, most interventions have been largely unsuccessful at the clinical arena.1 With the advent of...

Cardiac function is compromised by oxidative stress which occurs upon exposing the heart to ischemia reperfusion (I/R) for a prolonged period. The reactive oxygen species (ROS) that are generated during I/R incur extensive damage to the myocardium and result in subcellular organelle remodeling. The cardiac nucleus, glycocalyx, myofilaments, sarcoplasmic reticulum, sarcolemma, and mitochondria a...

Cardiac ischemia-reperfusion stimulates the renin-angiotensin system (RAS) associated with elevated levels of circulating angiotensin II. Numerous studies demonstrate that the antagonist for the angiotensin II type 1 receptor, losartan improves cardiac function in animal models of ischemia-reperfusion. Molecular mechanisms of the cardioprotective effects of RAS inhibitors on cardiac ischemia-re...

25 Emerging evidence highlights dietary flavonoids and nitrate as candidates that may explain at 26 least part of the cardioprotective effect of a fruit and vegetable diet. Nitric oxide (NO) plays a 27 pivotal role in cardiovascular health. Components of a fruit and vegetable diet that are 28 cardioprotective in part through effects on NO status could substantially reduce the 29 cardiovascular ...