background: left ventricular (lv) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of lv function. we sought to assess the impact of chronic pure mitral regurgitation (mr) on the torsional mechanics of the left human ventricle using tissue doppler imaging. methods: nineteen severe mr patients with a normal lv ejection fraction and 16 non-...

the left ventricular aneurysm is one of the most significant complications of myocardial infarction and is defined as the expansion of the ventricular wall. the coronary artery aneurysm is characterized by an abnormal dilation of the localized portion of the coronary artery, and its main cause is atherosclerosis. we herein report an unusual case of coronary artery and left ventricular aneurysms...

The sequence of atrial natriuretic factor (ANF) has been determined, as well as the complete structure of the rat and human complementary DNA and gene. ANF and ANF messenger RNA are present not only in atria but also in ventricles. The circulating form of ANF has been identified as the C-terminal of the molecule, ANF (Ser 99-Tyr 126). The isolated secretory granules of rat atrial cardiocytes co...

The sequence of atrial natriuretic factor (ANF) has been determined, as well as the complete structure of the rat and human complementary DNA and gene. ANF and ANF messenger RNA are present not only in atria but also in ventricles. The circulating form of ANF has been identified as the C-terminal of the molecule, ANF (Ser 99-Tyr 126). The isolated secretory granules of rat atrial cardiocytes co...

Pediatric cardiomyopathies are a group of conditions that are characterized by ventricular dilatation as seen in dilated cardiomyopathy or ventricular constriction as seen with restrictive cardiomyopathy and constrictive pericarditis. Patients might develop congestive heart failure. Echocardiography and magnetic resonance imaging are the main diagnostic modalities for cardiomyopathies in childr...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

The aim of the present study was to correlate in cardiomyopathic hamsters with congestive heart failure the levels of atrial and ventricular atrial natriuretic factor (ANF) messenger RNA (mRNA) with immunoreactive ANF (IR-ANF) plasma levels and the relative amount of IR-ANF released by the whole heart versus isolated ventricles in the Langendorff preparation. High-performance liquid chromatogra...

Ischemic and nonischemic cardiomyopathies are associated with significant morbidity and mortality in industrialized countries. Cardiomyopathies of primary origin, and more specifically the dilated form of the disease, have been associated with a number of gene defects in cytoskeletal, membrane, and sarcomeric proteins. Cardiomyopathies of secondary origin such as ischemic cardiomyopathy remain ...

abstract introduction: resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. the aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% o2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. methods: following 60 and 180 minutes of hyperoxia, rat hearts wer...

964 INTRODUCTION Cardiomyopathies are generally associated with a myocyte growth program that leads to an increase in the size of individual muscle cells. Individuals who have cardiac hypertrophy and cardiomyopathies are predisposed to the development of heart failure (Vasan et al., 1997). Heart failure affects 5.7 million individuals in the United States, has an annual economic health care bur...