Aims: Probiotics are viable and useful microorganisms, which are beneficial factors for human and animal health by altering their microbial flora. Most of the probiotics belong to a large group of bacteria in the human gastrointestinal tract. There are several clinical shreds of evidence that show anti-carcinogenic effects of probiotics through altering digestive enzymes, inhibition of carcinog...

Lewis et al. (1) state that compared to the fairly large number (> 400) of known rodent carcinogens, only a relatively small number of compounds (-20-30) have been shown to be carcinogenic in humans. From this comparison, the authors seem to infer that animal bioassay cancer findings overpredict for human carcinogens. Of course, for most animal carcinogens there are no available epidemiologic d...

The present study was undertaken to investigate the carcinogenic reaction of rats trcated with two different and differently acting carcinogens. This seemed to be of interest for various reasons. First, it would be possible to study the influence of one carcinogenic agent on the action of another. Although there are numerous publications on the action of carcinogenic substances on established t...

OBJECTIVES Night shift work involving circadian rhythm disruption has been classified by IARC as a probably carcinogenic to humans (Group 2A). Little is known about co-exposures of the night shift work in occupational settings. The aim of our study was to characterize night shift work systems and industrial exposures occurring in the manufacturing plants in Łódź, Poland, where night shift work ...

Renal excretion is one of the main elimination pathways for the toxic and carcinogenic chemical agents and metabolites to which man may be exposed. The urinary system is naturally often a target of such agents, the kidney being the filter in which they may be trapped, and the bladder a place where they may linger for a long time before being excreted. The likelihood that asbestos has a carcinog...

Using a case-control study comprising about 600 men with lung cancer in northern Sweden the potential risk of different occupations and groups of occupations was studied. Longitudinal data concerning occupation, employment, and smoking habits were obtained by questionnaires. Some occupational groups (underground miners, copper smelter workers, electricians, and plumbers) exposed to previously k...

inhibited by S-adenosyl-L-ethionine. The endogenous methyltransferase was able to transfer ethyl groups from the latter compound to histone but with very low efficiencycompared to the arginine methyltransferase reported previ ously. The histone lysine methyltransferase has a Km value of 3.0 /IM, and the K, value for S-adenosylethionine inhibition is 0.17 mM. Product inhibition by S-adenosylhomo...

Background: Radon and its short-lived decay products are considered as the important sources of public exposure to natural radioactivity. The synergistic interaction between tobacco smoking and radon is known to be an actual problem. This study has provided a mathematical description and prognosis of the carcinogenic effects after combined action of radon with smoking. Materials and Me...