High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well as irradiation...

OBJECTIVE To study the oncological outcome of the patients with unresectable locally advanced primary head and neck cancers invading the skull base, treated with particle radiotherapy. METHODS Fifty-seven patients with unresectable primary head and neck cancers invading the skull base received proton or carbon ion radiotherapy as definitive treatment at Hyogo Ion Beam Medical Center between 2...

Background The National Institutes for Quantum and Radiological Science Technology–National Institute of Sciences (QST–NIRS) has continuously investigated the undesired radiation exposure in ion beam radiotherapy mainly carbon-ion (CIRT). This review introduces our investigations on secondary neutron dose CIRT with broad scanning methods. Materials Methods ambient equivalents are evaluated ...

Heavy-ion radiotherapy has demonstrated the advantages over conventional radiotherapy , taking advantage of its improved dose conformation and higher relative biological effectiveness (Jakel et al., 2008). Telomerase is active in about 90% cancer cells which is important for cancer cells to maintain their immortalization. But the effects of heavy-ion radiation on telomere are largely unknown. U...

In radiotherapy with swift carbon ions very complex dose distributions are applied to a desired target volume. Up to now at the GSI radiotherapy project only regide target volumes in the skull of patients are treated. Extending the benefit of carbon ion radiotherapy to the whole patients body, problems of target motion as heart beat or breathing will occur. Using raster scan technique this moti...