BACKGROUND Combinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania. AIMS To assess the efficacy and safety of olanzapine plus carbamazepine in mixed and manic bipolar episodes. METHOD Randomised, double-blind, 6-week trial of olanzapine (10-30 mg/day) plus carbamazepine (400-1200 mg/day; n=58) v. placebo plus carbamazepine (n=60) followed ...

Seven treatment wetlands and a municipal wastewater plant (WWTP) were weekly monitored over the course of one year for removal conventional parameters, selected micropollutants (caffeine, ibuprofen, naproxen, benzotriazole, diclofenac, acesulfame, carbamazepine) biological effects. The wetland designs investigated include horizontal subsurface flow (HF) variety with intensification (aeration, t...

BACKGROUND Clarithromycin was used to treat lower respiratory tract infection in several developmentally disabled men who were also taking carbamazepine for seizure disorder. METHODS We studied retrospectively the use of clarithromycin in 5 patients taking carbamazepine. Because a drug interaction was suspected, the carbamazepine dosage was decreased during treatment, and serum levels were me...

Abstract An Upflow Anaerobic Sludge Blanket reactor combined with a two-stage membrane bioreactor were operated for 193 days in order to evaluate the biological removal of carbamazepine (CBZ) from low-strength municipal wastewater. The system worked three different organic load stages (0.7 ± 0.1 kg COD·m−3·d−1, 0.4 COD·m−3·d−1 and 0.0 COD·m−3·d−1) assess impact influent OLR on operational param...

In six depressed epileptic patients stabilised on carbamazepine therapy, addition of the antidepressant agent viloxazine (300 mg/day for three weeks) induced a marked (average 55%) increase in steady-state plasma carbamazepine concentration. The concentration of the active metabolite carbamazepine-10,11-epoxide also increased during viloxazine therapy, but to a lesser extent (16%). In three pat...

In this study, we investigated whether components of pomegranate could inhibit CYP3A-mediated drug metabolism. The ability of pomegranate to inhibit the carbamazepine 10,11-epoxidase activity of CYP3A was examined using human liver microsomes, and pomegranate juice was shown to be a potent inhibitor of human CYP3A. Addition of 25 microl (5.0% v/v) of pomegranate juice resulted in almost complet...

in this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported. the agglomerates were prepared by spherical crystallization method and thereafter dried without agitation at different temperature. an increased drying temperature did not affect the ...

a carbamazepine intoxication with attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. we report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. on admission, the patient was comatose and required ventilator support. hemoperfusion with...