Previous studies have shown that the fraction of hormone or drug that is plasma protein bound is readily available for transport through the brain endothelial wall, i.e., the blood-brain barrier (BBB). To test whether these observations are reconcilable with the free-hormone hypothesis, a tracer-kinetic model is used in the present investigations to analyze in vivo initial extraction data on BB...

capillary electrophoresis (ce) with indirect uv detection is an interesting analytical method for the analysis of drugs and pharmaceuticals. good and reproducible capillary quality is needed to develop robust methods and to facilitate method transfer in ce. it is widely accepted that preconditioning procedures are indispensable in capillary electrophoresis in order to achieve reproducibility of...

A glass capillary ultramicroelectrode (tip diameter approximately 1.2 microm) having an electrokinetic sampling ability is described. It is composed of a pulled glass capillary filled with an inner solution and three internal electrodes (Pt working and counter electrodes and an Ag/AgCl reference electrode). The voltammetric response of the capillary electrode is based on electrokinetic transpor...

A mathematical model for solute distribution within the tissue due to combined processes of diffusion and convective transport through the tissue, through the capillary wall, and by lymphatic absorption, during the exchange of the solute between an organ and external medium is applied for the description of the transport of small, middle and macro molecules. The analytical solutions of the tran...

The transport of long gas bubbles, suspended in liquid, through symmetric bifurcations, is investigated experimentally and theoretically as a model of cardiovascular gas bubble transport in air embolism and gas embolotherapy. The relevant dimensionless parameters in the models match the corresponding values for arteries and arterioles. The effects of roll angle (the angle the plane of the bifur...

The Swedish hardwood sawmills are today experiencing problems of finding profitable markets for products containing for instance knots and red or brown heartwood. By using hardwood outdoors, it would be possible to expand the market of hardwood with new products that may set other requirements on the wood than the present use. In Sweden today, hardwood is normally used in furniture, joinery, fl...

BACKGROUND Laboratory test in transport is a critical component of patient care, and capillary blood is a preferred sample type particularly in children. This study evaluated the performance of capillary blood testing on the epoc Point of Care Blood Analysis System (Alere Inc). METHODS Ten fresh venous blood samples was tested on the epoc system under the capillary mode. Correlation with GEM ...