AIM The purpose of this study was to investigate possible effects of green tea extract on the activities of DNA turn-over enzymes, namely adenosine deaminase (ADA) and xanthine oxidase (XO) in gastric and colon tissues from patients with stomach and colon cancer. MATERIALS AND METHODS Six cancerous and 6 non-cancerous adjacent human gastric tissues, and 7 cancerous and 7 non-cancerous adjacen...

BACKGROUND MicroRNA-106b (miR-106b) is thought to be an oncogenic microRNA that promotes tumor growth and metastasis. The potential predictive value of miR-106b was studied in colonic cancer patients. METHODS The expression of miR-106b was examined in 180 colonic cancer cases using in situ hybridization (ISH) technique and was evaluated semi-quantitatively by examining the staining index. The...

The ectopic activation of NR0B1 is involved in the development of some cancers. However, the regulatory mechanisms controlling NR0B1 expression are not well understood. Therefore, the epigenetic modifications promoting NR0B1 activation were examined in this study. NR0B1 protein was detected in cancerous tissues of more than 50% of human lung adenocarcinoma (ADCA) cases and tended to be expresse...

Recently, spectroscopic analysis of cancer tissues has received considerable attention to be a diagnosis technique due to its sensitivity to biochemical variations in the samples. In this study Fourier Transform Infrared Spectroscopy (FTIR) was used to analyze, spectroscopicaly, a number of bladder cancer tissues compared with normal bladder tissues. Twenty samples were collected from ten patie...

We studied the time-resolved polarization-dependent fluorescence spectroscopy of receptor-targeted contrast agents (Cybesin and Cytate) bound with prostate cancer cells in prostate tissue. An analytical model dealing with highly viscous tissue media was developed and used to investigate the rotation times and fluorescence anisotropies of the receptor-targeted contrast agents in prostate tissue....

The supernatants of the homogenates from normal and cancerous human prostatic tissue run on polyacrylamide gel electrophoresis have 2 major electrophoretic bands when stained for prostatic acid phosphatase. The ratios of the electrophoretically distinguishable isoenzymes differ in normal and cancerous tissues. Similar distinctions between isoenzymes in normal and cancerous prostates are observe...