نتایج جستجو برای: canavan disease
تعداد نتایج: 1490117 فیلتر نتایج به سال:
A number of nutrient media have been described by Goodman (1954), Katagiri (1954), Niedercorn (1952), Petty et al. (1953), Van Dyke and De Somer (1952), and others that allow Streptomyces aureofaciens Duggar to grow in aerated, liquid culture and to accumulate substantial quantities of 7-chlorotetracycline.' The concentrations of 7-chlorotetracycline accumulated on these different media vary fr...
Canavan disease (CD) (OMIM 271900) is an autosomal recessive leucodystrophy characterised by swelling and spongy degeneration of the white matter of the brain. The biochemical marker for the disorder is increased level of N-acetylaspartic acid (NAA) in cerebrospinal fluid and urine owing to aspartoacylase (ASPA) deficiency. 2 The disease is caused by mutations in the gene encoding the enzyme as...
Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary considerably. Here we report on a novel targeted aspa mouse mutant expressing the bacterial β-Gala...
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