The chick embryo chorioallantoic membrane (CAM) model is extensively used in human medicine in preclinical oncological studies. The CAM model has several advantages: low cost, simple experimental approach, time saving and following "3R principles". Research has shown that the human osteosarcoma cell lines U2OS, MMNG-HOS, and SAOS can form tumors on the CAM. In veterinary medicine, this has been...

Calmodulin (CaM) is the major pathway that transduces intracellular Ca2+ increases to the activation of a wide variety of downstream signaling enzymes. CaM and its target proteins form an integrated signaling network believed to be tuned spatially and temporally to control CaM's ability to appropriately pass signaling events downstream. Here, we report the spatial diffusivity and availability o...

The detailed dynamic and thermodynamic space–time structures of the Madden–Julian oscillation (MJO) as simulated by the superparameterized Community Atmosphere Model version 3.0 (SP-CAM) are analyzed. Superparameterization involves substituting conventional boundary layer, moist convection, and cloud parameterizations with a configuration of cloud-resolving models (CRMs) embedded in each genera...

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The community assessment model (CAM) for odor dispersion is a tool to assist in the siting of swine production facilities. CAM considers the size and type of a swine production system, local historical weather conditions, and odor control implementation. It predicts the number of hours of exposure to various levels of odor, by month, for each receptor in a given community. A follow‐up survey of...

A regulatory region involved in both autoinhibition and calmodulin (CaM) binding has previously been identified in the multifunctional Ca2+/CaM-dependent protein kinase (CaM kinase II). We have tested the role of various segments of the regulatory region in autoinhibition by the analysis of a series of truncation, substitution, and deletion mutants of the CaM kinase II alpha subunit (CaM kinase...

How linguistic representations in memory are searched and retrieved during sentence processing is an active question in psycholinguistics. Much work has independently suggested that retrieval operations require constant-time computations, are susceptible to interference, and operate under the constraint of a severely limited focus of attention. These features suggest a model for sentence proces...

Calmodulin (CaM) is a ubiquitous intracellular calcium sensor that directly binds to and modulates a wide variety of ion channels. Despite the large repository of high-resolution structures of CaM bound to peptide fragments derived from ion channels, there is no structural information about CaM bound to a fully folded ion channel at the plasma membrane. To determine the location of CaM docked t...

Voltage-dependent calcium channels (VDCCs) are key elements in epileptogenesis. There are several binding-sites linked to calmodulin (CaM) and several potential CaM-dependent protein kinase II (CaMKII)-mediated phosphorylation sites in CaV1.2. The tremor rat model (TRM) exhibits absence-like seizures from 8 weeks of age. The present study was performed to detect changes in the Ca 2+ /CaV1.2/CaM...

UNLABELLED For many years the laboratory mouse has been used as the standard model for in vivo oncology research, particularly in the development of novel PET tracers, but the growth of tumors on chicken chorioallantoic membrane (CAM) provides a more rapid, low cost, and ethically sustainable alternative. For the first time, to our knowledge, we demonstrate the feasibility of in vivo PET and CT...