BACKGROUND Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. We report a case which clearly illustrates that knowledge of the u...

A renal transplant patient who presented with a painful, proximal myopathy due to systemic calciphylaxis is described. The myopathy preceded the characteristic skin and soft tissue necrosis. Systemic calciphylaxis should be considered in a dialysis or a renal transplant patient presenting with a painful proximal myopathy even in the absence of necrotic skin lesions.

Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity ...

Calciphylaxis is a rare and debilitating vasculopathy predominantly seen in patients with renal failure. The proposed mechanism of injury is active vascular calcification with associated elevated parathyroid hormone, hypercalcemia, or hyperphosphatemia. With improved pharmacologic agents including non-calcium containing phosphate binders, vitamin D analogues, calcimimetics, and bisphosphonates,...

Calciphylaxis is a lethal disorder seen in patients with end-stage renal disease and is characterized by painful necrotic skin lesions. The pathophysiology is still unknown. Elevated calcium, phosphorous and parathormone appear to play a role in causing small and medium sized vasculopathy. Diagnosis is delayed, prognosis is poor and mortality remains high. In this article we describe the case o...

We report the case of a 59-year-old woman with end-stage renal disease who presented with bilateral medial calf tenderness and subsequent development of a large necrotic plaque that was proven at biopsy to be calciphylaxis. A radionuclide bone scan contributed to management by helping establish the diagnosis. Calciphylaxis is a highly morbid small vessel vasculopathy encountered in patients on ...

however there are adequate discussions of epidemiology, phage anatomy, and the relation of viruses to cancer, as well as other topics which will intrigue the more medically oriented reader. A particularly valuable aspect of the book is that facts are discussed in relation to the research by means of which they were originally discovered or tested. The research is treated both by topic and chron...

Fig. 1. Dry gangrene of the fingers (A and B) and dusky red discoloration of the right great toe (C) are shown. Progression of the gangrene of the fingers (D and E) and development of gangrenous necrosis of the toes (F) are shown. Plain radiographs demonstrating marked vascular calcification of the hands and feet (G–J). Skin biopsy revealing calcification (K) and microthrombosis (L and M) of sm...

We have found that nanobacteria, recently discovered Gram-negative atypical bacteria, can cause local calciphylaxis on the mitral valve in a setting of high-calcium X phosphorous product in the blood. We present the case of a 33-year-old man with diabetic renal failure on continuous ambulatory peritoneal dialysis who died as a result of multiple brain infarcts due to embolizations from mitral v...