BACKGROUND The modulation of adenosine receptors has been proposed as new therapeutic target for chronic obstructive pulmonary disease, but studies in humans were negative. Caffeine is widely consumed and acts by non-selective modulation of these receptors, allowing for a non-interventional evaluation of the purinergic effects on COPD. We evaluated the effects of chronic caffeine consumption on...

This study was designed to examine the effect of exercise intensity on the magnitude and duration of excess postexercise oxygen consumption (EPOC) in women. On separate days and in a counterbalanced order, seven moderately active young adult women performed a 850 kJ cycle ergometer exercise at an intensity of 40 or 60% of their previously determined peak oxygen uptake (VO2). Baseline VO2 and he...

- verapamil produces a sustained contraction in isolated biventer-cervicis muscle of chickens between 2-8 days old. from cumulative dose-response curves, ed50 of was calculated for this effect of verapamil. when isolated chicken biventer-cervicis muscle was electrically stimulated, verapamil had no effect on twitch contractures but increased the base line tone of the muscle. glycerol treatment ...

Ins(1,4,5)P3 (InsP3)-induced Ca2+ release and [3H]InsP3 binding were measured in rat cerebellar microsomes in the presence or absence of caffeine. The quantal Ca2+ release was shown to occur in an apparently co-operative fashion with a Hill coefficient (h) of 2.2. Half-maximal Ca2+ release was observed at 900 nM-InsP3. Addition of caffeine caused changes both to the concentration of InsP3 requi...

background: in recent years, concerns have been raised about human reproductive disorders. caffeine consumption is increasing by the world’s population and there is a relationship between caffeine intake and adverse reproductive outcomes. the aim of this study was to evaluate the effects of caffeine on implantation sites, number of live births, birth weight, crown-rump length (crl) and abnormal...

Members of the family Embiotocidae exhibit a distinct gait transition from exclusively pectoral fin oscillation to combined pectoral and caudal fin propulsion with increasing swimming speed. The pectoral-caudal gait transition occurs at a threshold speed termed U(p-c). The objective of this study was to partition aerobic and anaerobic swimming costs at speeds below and above the U(p-c) in the s...

BACKGROUND Caffeine's properties as an analgesic adjuvant with nonsteroidal anti-inflammatory drugs/acetaminophen are well documented. However, little clinical research has explored caffeine's effects on opioid analgesia. This study assessed the effects of caffeine consumption on pain and other symptoms in opioid-using and nonusing chronic pain patients meeting the survey criteria for fibromyal...

Caffeine is a marker drug for testing the activity of CYP1A2 (3-N-demethylation) in humans and rats. Moreover, CYP3A seems to be essential for its metabolism (8-hydroxylation). In the case of 1-N- and, in particular, 7-N-demethylation of caffeine, apart from CYP1A2, other CYP isoenzymes play a considerable role, probably CYP2B and/or CYP2E1. The aim of the present study was to investigate the i...