Individual mammalian neurons stochastically express distinct repertoires of α, β, and γ protocadherin (Pcdh) proteins, which function in neural circuit assembly. We report that all three subfamilies of clustered Pcdhs can engage in specific homophilic interactions, that cell surface delivery of Pcdhα isoforms requires cis interactions with other Pcdhs, and that the extracellular cadherin domain...

Circumanal gland (CG) tumors are common neoplasms of older dogs. Of these, only circumanal carcinomas show clear metastatic potential, and even so metastases seem to be uncommon. Epithelial-mesenchymal transition (EMT) is a process that facilitates the initial steps metastasis, date it has not been systematically investigated in CG tumors. Insight into occurrence this would valuable asset under...

Inflammatory breast cancer is a highly aggressive form of that forms clusters tumor emboli in dermal lymphatics and readily metastasizes. These cancers express high levels E-cadherin, the major mediator adherens junctions, which enhances formation emboli. Previous studies suggest E-cadherin promotes when balance between apical basolateral cadherin complexes disrupted. Here, we used immunohistoc...

Graphical Abstract Regulatory effect between E-cadherin and AGO2.

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

Renal cell carcinomas (RCCs) primarily express cadherin-6 and N-cadherin rather than E-cadherin, and the aberrant expression of cadherin-6 correlates with a poor prognosis in patients with E-cadherin-absent RCC. However, the role of N-cadherin in RCC has not yet been elucidated. In this study, we analyze the expression pattern of N-cadherin in surgical RCC specimens and discuss the function of ...

The two major cadherins of endothelial cells are neural (N)-cadherin and vascular endothelial (VE)- cadherin. Despite similar level of protein expression only VE-cadherin is located at cell-cell contacts, whereas N-cadherin is distributed over the whole cell membrane. Cotransfection of VE-cadherin and N-cadherin in CHO cells resulted in the same distribution as that observed in endothelial cell...

R-cadherin was originally identified as a chicken cadherin expressed by the retina. Here, we describe the identification of a mouse homologue of R-cadherin. We isolated mouse cDNAs encoding a cadherin with 94% identity in amino acid sequence to the chicken R-cadherin, and defined this molecule as mouse R-cadherin. L cells transfected with the mouse R-cadherin cDNA acquired a cadherin-mediated c...

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursued studies of cis sequences and transcription factors regulating E-cadherin ex...

Masataka Saito*, Dana K. Tucker*, Drew Kohlhorst, Carien M. Niessen and Andrew P. Kowalczyk Departments of Cell Biology, Dermatology and the Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologn...