Although there are many types of ADD/ADHD, a common form of ADD (CADD) in children (high theta/beta ratio at Cz) can be successfully treated in less than 15 sessions. The increased efficacy relative to the standard beta enhance/theta suppress protocol results from precise but brief diagnosis, home cognitive exercises with a theta suppression harmonic, disentraining and/or entraining visual stim...

Computer-aided drug design (CADD) is an exciting and diverse discipline where various aspects of applied and basic research merge and stimulate each other. The latest technological advances (QSAR/QSPR, structure-based design, combinatorial library design, cheminformatics & bioinformatics); the growing number of chemical and biological databases; and an explosion in currently available software ...

Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional Chinese medicine (TCM) for novel lead compounds. Despite the growing number of studies on TCM, there is no free 3D small molecular structure database of TCM available for virtual ...

Measures of general deleteriousness, like CADD or PolyPhen, have become indispensable tools in the interpretation of genetic variants. However, these measures say little about where in the organism these deleterious effects will be most apparent. An additional, complementary measure is needed to link deleterious variants (as determined by e.g., CADD) to tissues in which their effect will be mos...

Initially, the design of new drugs was based on the prototypical molecule, usually a natural product and making structural modifications. For designing of new drugs the understanding of the etiology of the disease and the structure of the receptor where the ligand (drug) will bind is very much important. Now a day, there is increasing computational power coupled with applicable software, has le...

Utility of combined annotation-dependent depletion (CADD) score was recently reported to rank pathogenicity as C-scores ranging 1-99 for both confirmed deleterious mutation. Using C-scores for BRCA1/2 variants, we tried to constitute the classification system for variant of uncertain significance (VUS), which had been a major problem of genetic testing for hereditary breast and/or ovarian cance...

Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery. In this paper, we computationally evaluated and reported the inhibitory activity found in meridianins A-G, a group of marine indole alkaloids...

Modern drug discovery is characterized by the production of vast quantities of compounds and the need to examine these huge libraries in short periods of time. The need to store, manage and analyze these rapidly increasing resources has given rise to the field known as computer-aided drug design (CADD). CADD represents computational methods and resources that are used to facilitate the design a...