نتایج جستجو برای: c6 glioma

تعداد نتایج: 45680  

Journal: :Chinese medical journal 2011
Suo-Jun Zhang Fei Ye Rui-Fan Xie Feng Hu Bao-Feng Wang Feng Wan Dong-Sheng Guo Ting Lei

BACKGROUND Glioma stem cell (GSC) hypothesis posits that a subpopulation of cells within gliomas have true clonogenic and tumorigenic potential. Significantly, a more controversial correlate to GSC is that cells in different culture conditions might display distinct stem cell properties. Considering these possibilities, we applied an approach comparing stem cell characteristics of C6 glioma cel...

Journal: :Journal of biomedical materials research. Part A 2012
Jing Xu Pengjuan Xu Zhigui Li Jie Huang Zhuo Yang

Hydroxyapatite (HA) nanoparticles have been reported to exhibit anti-tumor effects on various human cancers, but the effects of HA on glioma cells remain unclear. The aim of this study was to explore whether HA can inhibit the proliferation and induce the apoptosis of C6 cells. Use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that HA induced C6 cell ...

Journal: :Oncology reports 2012
Keming Yu Zhao Chen Xueke Pan Ying Yang Sijia Tian Jing Zhang Jian Ge Bala Ambati Jing Zhuang

Tetramethylpyrazine (TMP) is the major component extracted from the Chinese herb Chuanxiong. Increasing numbers of studies have indicated that tetramethylpyrazine hydrochloride (TMPH) has anticancer effects. However, the molecular mechanisms underlying the actions of TMPH have not been fully elucidated. In this study, using real-time RT-PCR and we...

2013
Mónica Díaz-Coránguez José Segovia Adolfo López-Ornelas Henry Puerta-Guardo Juan Ludert Bibiana Chávez Noemi Meraz-Cruz Lorenza González-Mariscal

Transit of human neural stem cells, ReNcell CX, through the blood brain barrier (BBB) was evaluated in an in vitro model of BBB and in nude mice. The BBB model was based on rat brain microvascular endothelial cells (RBMECs) cultured on Millicell inserts bathed from the basolateral side with conditioned media (CM) from astrocytes or glioma C6 cells. Glioma C6 CM induced a significant transendoth...

Journal: :International journal of oncology 2010
Mine Erguven Nuray Yazihan Esin Aktas Akin Sabanci Chiang J Li Gulperi Oktem Ayhan Bilir

The purpose of the study was to investigate whether carvedilol has an antiproliferative effect alone and whether carvedilol provides an additive, synergistic or antagonistic effect on imatinib mesylate-induced cytotoxicity in both C6 glioma monolayer and spheroid culture. The C6 rat glioma chemoresistant experimental brain tumour cell line, that is notoriously difficult to treat with combinatio...

Journal: :Cancer research 2001
K Ozawa Y Tsukamoto O Hori Y Kitao H Yanagi D M Stern S Ogawa

Expression of angiogenic factors such as vascular endothelial growth factor (VEGF) under conditions of cell stress involves both transcriptional and translational events, as well as an important role for inducible endoplasmic reticulum (ER) chaperones. Coexpression of VEGF and 150-kDa oxygen-regulated protein (ORP), a novel ER chaperone, in human glioblastoma suggested a link between angiogenes...

Journal: :Neurologia medico-chirurgica 1986
T Yoshida K Shimizu Y Ushio T Hayakawa H Mogami Y Sakamoto

Reserpine has enhanced the cytotoxicity of 1 (4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2 chloroethyl)-3-nitrosourea hydrochloride (ACNU) in both ACNU-resistant sublines of C6 and 9L glioma cells (C6/ACNU, 9L/ACNU) and could completely overcome ACNU resistance in vitro. When reserpine was added to the culture in the concentration of 10ƒÊM, the concentrations of drug required for 50% inhibition ...

2001
Kentaro Ozawa Yoshitane Tsukamoto Osamu Hori Yasuko Kitao Hideki Yanagi David M. Stern Satoshi Ogawa

Expression of angiogenic factors such as vascular endothelial growth factor (VEGF) under conditions of cell stress involves both transcriptional and translational events, as well as an important role for inducible endoplasmic reticulum (ER) chaperones. Coexpression of VEGF and 150-kDa oxygen-regulated protein (ORP), a novel ER chaperone, in human glioblastoma suggested a link between angiogenes...

Journal: :Physiological research 2002
R Malík K Vlasicová A Sedo

There are conflicting results concerning the receptor subtype(s) involved in calcium-mediated endothelin signaling in the glial cells. In order to elucidate the role of endothelin A and B receptors in these processes, we have studied the effect of a complex spectrum of endothelin receptor ligands on intracellular calcium concentration changes in proliferating and differentiated C6 rat glioma ce...

Journal: :Oncology reports 2010
Xuezhe Han Sung H Yoon Yan Ding Tae G Choi Won J Choi Yun H Kim Young-Joo Kim Young-Buhm Huh Joohun Ha Sung S Kim

Glioma is the most common type of brain tumors in adults, and treatment of high-grade gliomas is still palliative. Studies to date have revealed only modest effect in attenuating growth of these tumors with single agent therapy, but combination treatment appears to be more effective. Cyclophilin A (CypA), a target of immunosuppressive drugs cyclosporin A (CsA) and sanglifehrin A (SFA), is an in...

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