Peroxisome Proliferator Activated Receptors Gamma (PPAR-ᵞ) is a nuclear transcription factor, which Protein receptors for insulin and have significant role in resistance Type 2 Diabetes mellitus addition to the of gene encoded differentiation Adipocyte development Adipose tissue. at present research has been detected substitution silent mutation C T exon 6 PPAR-ᵧ 111 women, including 73 obese w...

GABA(C) receptors are the least studied of the three major classes of GABA receptors. The physiological roles of GABA(C) receptors are still being unravelled and the pharmacology of these receptors is being developed. A range of agents has been described that act on GABA(C) receptors with varying degrees of specificity as agonists, partial agonists, antagonists and allosteric modulators. Pharma...

Activation of AT 1 (type Ang) receptors stimulates cardiomyocyte hypertrophy in vitro. Accordingly, it has been suggested that regression cardiac associated with renin-Ang system blockade is due to inhibition cellular actions Ang II the heart, above and beyond their effects reduce pressure overload. We generated 2 distinct mouse lines cell-specific deletion 1A receptors, from cardiomyocytes. In...

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [438, 437, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, family small cytokines typically possessing chemotactic activity for leukocytes. Additional hematopoietic and non-hematopoietic roles have been identified many chemokines in areas embryonic development, immune cell pr...

there is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. dopamine is one of the most important neurotransmitters. five different dopamine receptor genes (drd1, drd2, drd3, drd4, and drd5) have been recognized and cloned. the expression of the dopamine receptors is well characterized in the brain but little work has been done to examine t...