For years an assumption was made that C-peptide, a byproduct of insulin biosynthesis, possessed no appreciable physiologic role. As other contributions in this volume amply testify, the time has come to re-evaluate that notion. C-peptide either directly through interaction with its specific cell-surface receptor or indirectly through an interaction with a related membrane entity, exerts a uniqu...

C-peptide levels can initially be normal or increased in type 2 diabetes mellitus (T2DM), which is connected to insulin resistance; however, as the condition progresses, these may fall. According studies, kidney failure has its primary cause, accounting for 44% of all new cases. In addition, it's critical strictly regulate blood sugar and lower protein intake. Along with insulin, pancreas produ...

Development of peptide therapeutics generally involves screening excipients that inhibit peptide-peptide interactions, hence aggregation, and improve stability. We used the therapeutic plectasin to develop a fast method combines microscale thermophoresis titration assays molecular dynamics simulations relatively rank with respect binding affinity study key peptide-excipient interaction hotspots...

abstract background antibiotic resistance makes antimicrobial peptides (amps) agents an alternative for treatment of pathogenic diseases. they are isolated from various animals invertebrates, vertebrates and plants. the present study shows the electrophoretic pattern of protein and peptides from vicia faba seed and reports our first attempt to study the antibacterial activity of vicia faba seed...