Background: Acquired hemophilia A (AHA) is a rare bleeding disease due to autoantibodies directed against clotting factor VIII (FVIII). Treatment of AHA consists inhibitor eradication with immunosuppressive therapy (IST) and prompt control obtained bypassing agents or recombinant porcine FVIII (rpFVIII). The latter has recently been licensed for management acute in AHA. Unlike treatment agents,...

While most other areas of penetration testing are well understood, and their methodologies well documented, little information regarding testing and bypassing malware defenses is available in the public domain. Still, malware incidents remain the most expensive type of incidents caused by outsiders, while also being the most frequent type of incidents occurring to organizations. In addition, si...

A mathematical model is presented for calculating the change in volume and sand-bypassing rate at ebb-tidal shoals. Conceptually and mathematically, the ebb-tidal shoal is distinguished from bypassing bars that emerge from it and from attachment bars where the bypassing bars merge with the beach. The volumes and bypassing rates of these morphologic entities are calculated by analogy to a reserv...

Article history: Received Accepted Available online 20 Nov. 2014 19 Dec. 2014 25 Dec. 2014 Based on the simplification of the addition operations in a low-power bypassing-based multiplier, a low-cost low-power bypassing-based multiplier is proposed. Row-bypassing multiplier, column-bypassing multiplier, 2-Dimensional bypassing multiplier and braun multipliers are implemented in CMOS and GDI tec...

The gene product 60 (gp60) of bacteriophage T4 is synthesized as a single polypeptide chain from a discontinuous reading frame as a result of bypassing of a non-coding mRNA region of 50 nucleotides by the ribosome. To identify the minimum set of signals required for bypassing, we recapitulated efficient translational bypassing in an in vitro reconstituted translation system from Escherichia col...

DOSE (Dosing Observational Study in Hemophilia) was a prospective, observational diary study designed to evaluate the use of bypassing agents in patients prescribed recombinant activated factor VII (rFVIIa) as first-line treatment in the home setting. Patients with congenital hemophilia with inhibitors and caregivers participated, and as part of the study, the time spent preparing and administe...

The XML port scanning technique described in this paper allows an attacker to utilise an XML parser to execute port scanning of systems behind a restrictive perimeter firewall. While the technique relies on some reasonably specific implementation details in order to be exploitable remotely, it is potentially applicable to any application that accepts XML document inputs. Several workarounds exi...

Up to 30% of haemophilia A patients and up to 3% of haemophilia B patients develop neutralizing antibodies (inhibitors) to factor VIII or factor IX, rendering replacement therapies ineffective and making the management of bleeding episodes particularly challenging.1–3While patients with low titre inhibitors may benefit from higher doses of factors VIII or IX, patients with higher antibody level...