PURPOSE The present study involves preparation and evaluation of diclofenac buccal-mucoadhesive microparticles for prolongation of buccal residence time. METHODS The microparticles were prepared by modified double-emulsion dehydration method (O1/W/O2) using sodium carboxymethylcellulose (CMC-Na) as mucoadhesive polymer. Calcium chloride was used as a cross-linking agent. Buccal-mucoadhesive m...

Buccoadhesive buccal delivery systems for isosorbide dinitrate in the form of unidirectional buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like Carbopol 934P and polyvinyl pyrrolidone by using two different plasticizers propylene glycol and diethyl phthalate. Unidirectional re...

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

In this thesis, the strength-enhancing mechanisms of dry binders in direct compression were studied. The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol. The proposed simplified tablet model describing the fracture path in a tablet during strength testing offers an expl...

background: the poisoning is mostly due to suicide and is observed in younger age groups. the systemic manifestations of alp poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ards. the clinical hallmark of cardiotoxicity is arrhythmia. the aim of this study was to investigate cardiac arrhythmias in patients poisoned with alp who were admitted to razi hosp...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...

background: aluminum phosphide or rice tablet is one of the most common pesticides which leads to accidental or intentional acute intoxication and finally death. in this paper, we describe a successful management of intoxication with rice tablet in a young girl. case presentation: a 14-year-old girl was admitted due to consumption of rice tablet. gastric washing with two vials of sodium bicarbo...

Pharmacists have been splitting scored tablets to individualize and titrate dosages since the end of the pill-rolling era. We have generally accepted that scored tablets may be evenly divided, resulting in 2 half-tablets containing one-half of the whole tablet strength. Slight powdering is unavoidable, but it is generally accepted that loss of a few molecules of active drug is not likely to be ...