Abstract: Aim and Objectives: The main motto of this work was to search the additive effect Datura stramonium leaves mucilage in making buccoadhesive film by taking Aceclofenac as a model drug. Materials Methods: Nine formulations buccal films were made using Carbopol 934 P varying proportions Ethyl Cellulose D. mucilage. judged for compatibility studies physical constraints including content d...

Breakthrough pain, a transitory severe pain with the background of otherwise controlled persistent pain has a prevalence between 52% and 67% in outpatients with cancer. Medications for such sudden-onset pain require non-invasive delivery of a potent and short-acting opioid for rapid pain relief. Although oral transmucosal delivery of fentanyl citrate (OTFC) has been shown to provide better pain...

Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly. Buccal films are one such system responsible for systemic drug delivery at the desired site of action by avoiding hepatic first-pass metabolism. Metformin hydrochloride (Met), an antidiabetic drug, has poor bioavailabil...

is perhaps the most preferred by patients and clinicians alike. However, peroral administration of drugs has disadvantages, such as hepatic first-pass metabolism and enzymatic degradation within the gastrointestinal (GI) tract, that prohibit oral administration of certain classes of drugs, especially peptides and proteins. Consequently, other absorptive mucosa are considered as potential sites ...

Absorption of drugs through the oral cavity was noted as early as 1847 and systemic studies of oral cavity absorption were first reported in 1935 [1]. Since then, substantial effort has been focused on drug absorption from a drug delivery system in a particular region of the oral cavity [2-5]. As a site for drug delivery, the oral cavity offers many advantages over other routes of drug administ...