نتایج جستجو برای: btc

تعداد نتایج: 990  

2016
Qiwei Li Ming Zhan Wei Chen Benpeng Zhao Kai Yang Jie Yang Jing Yi Qihong Huang Man Mohan Zhaoyuan Hou Jian Wang

Biliary tract cancer (BTC) is a highly malignant cancer. BTC exhibits a low response rate to cisplatin (CDDP) treatment, and therefore, an understanding of the mechanism of CDDP resistance is urgently needed. Here, we show that BTC cells develop CDDP resistance due, in part, to upregulation of myeloid cell leukemia 1 (Mcl-1). Phenylethyl isothiocyanate (PEITC), a natural compound found in water...

Journal: :Journal of the American Chemical Society 2010
Leslie J Murray Mircea Dinca Junko Yano Sachin Chavan Silvia Bordiga Craig M Brown Jeffrey R Long

Reaction of Cr(CO)(6) with trimesic acid in DMF affords the metal-organic framework Cr(3)(BTC)(2).nDMF (BTC(3-) = 1,3,5-benzenetricarboxylate), which is isostructural to Cu(3)(BTC)(2).3H(2)O. Exchanging DMF for methanol and heating at 160 degrees C under dynamic vacuum for 48 h results in the desolvated framework Cr(3)(BTC)(2). Nitrogen gas adsorption measurements performed at 77 K revealed a t...

ژورنال: شیمی کاربردی 2019

در این مقاله با روشی ساده و ملایم ترکیبات 5،1-بنزودی آزپین با استفاده از تراکم مشتقات اورتو فنیلن دی آمین و کتون های خطی یا حلقوی در مجاورت مقادیر کاتالیزوری از چارچوب فلز-آلی نانوحفره Zn3(BTC)2 در حلال اتانول و دمای50 درجه سانتیگراد سنتز شدند. تمام محصولات با بازدههای بالا (%95-86) بهدست آمدند. چارچوب فلز-آلی نانوحفره Zn3(BTC)2 به کار برده شده، دارای مزایایی از جمله غیرسمی بودن، پایدار بودن در...

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2009
Mitsugi Shimoda Tokihiko Sawada Keiichi Kubota

PURPOSE To investigate a rationale of pancreatobiliary cancers, thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) concentrations in cancer tissues were evaluated. PATIENTS AND METHODS Twenty-nine patients with pancreatic cancer (PC) and 43 with biliary tract cancer (BTC; 27 cases of bile duct cancer, 8 of gallbladder cancer and 8 of cancer of the papillary area) were include...

2016
Ah-Rong Nam Ji-Won Kim Yongjun Cha Hyerim Ha Ji Eun Park Ju-Hee Bang Mei Hua Jin Kyung-Hun Lee Tae-Yong Kim Sae-Won Han Seock-Ah Im Tae-You Kim Do-Youn Oh Yung-Jue Bang

Currently, there is no validated therapeutic target for biliary tract cancer (BTC). This study aimed to investigate the pre-clinical and clinical implication of HER2 as a therapeutic target in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 and SNU-2773, from gallbladder cancer patients. SNU-2670 and SNU-2773 cells were sensitive to trastuzumab, dacomitinib, and afatinib c...

2014
Neomal S Sandanayake Stephane Camuzeaux John Sinclair Oleg Blyuss Fausto Andreola Michael H Chapman George J Webster Ross C Smith John F Timms Stephen P Pereira

BACKGROUND The aim of this discovery study was the identification of peptide serum biomarkers for detecting biliary tract cancer (BTC) using samples from healthy volunteers and benign cases of biliary disease as control groups. This work was based on the hypothesis that cancer-specific exopeptidases exist and that their activities in serum can generate cancer-predictive peptide fragments from c...

Journal: :Chemical communications 2010
Lik H Wee Sneha R Bajpe Nikki Janssens Ive Hermans Kristof Houthoofd Christine E A Kirschhock Johan A Martens

Nanomaterial of Cu(3)(BTC)(2) (BTC = benzene tricarboxylic acid) incorporating Keggin heteropolyacid conveniently prepared at room temperature and recovered by freeze drying outperforms ultrastable Y zeolite in acid catalysed esterification reaction.

2013
Ya Hong Wu Gui Ping Tan Shan Ling Tong Yan Yan

A coordination polymer {Zn(II) 3 [(Btc) 2 (Bzim) 3 ]} n (Btc = 1, 3, 5-benzene tricarboxylic acid, Bzim = benzimidazole) was successfully assembled in crystal state by hydrothermal method. Its molecular configuration was well defined by X-ray diffraction, element analysis and IR determination. Investigation results indicated that this coordination polymer possessed photoluminescence and thermal...

Journal: :The EMBO journal 1997
M Alimandi L M Wang D Bottaro C C Lee A Kuo M Frankel P Fedi C Tang M Lippman J H Pierce

Interleukin-3 (IL-3)-dependent murine 32D cells do not detectably express epidermal growth factor receptors (EGFRs) and do not proliferate in response to EGF, heregulin (HRG) or other known EGF-like ligands. Here, we report that EGF specifically binds to and can be crosslinked to 32D transfectants co-expressing ErbB2 and ErbB3 (32D.E2/E3), but not to transfectants expressing either ErbB2 or Erb...

2016
Wei Wang Ming Zhan Qi Li Wei Chen Huiling Chu Qihong Huang Zhaoyuan Hou Mohan Man Jian Wang

Chemoresistance is common in patients with biliary tract cancer (BTC) including gallbladder cancer (GBC) and cholangiocarcinoma (CC). Therefore, it is necessary to identify effective chemotherapeutic agents for BTC. In the present study, we for the first time tested the effect of farnesoid X receptor (FXR) agonists GW4064 and CDCA (chenodeoxycholic acid) in combination with cisplatin (CDDP) on ...

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