in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

The first synthesis of (+/-)-robinlin (1), a novel homo-monoterpene with strong bioactivity in the brine shrimp lethality test, was achieved by starting from 3-isobutyloxy-2,6,6-trimethyl-2-cyclohexen-1-one (2).

The organic extracts of leaves and roots of five plants used for treating malaria in Central, Nairobi and Rift Valley Provinces, Kenya were tested for brine shrimp lethality and in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 60% were toxic to the brine shrimp (LC(50)<30 microg/ml) and eight out of ten plant pa...

  Background: Achillea talagonica (Asteraceae) is an endemic herbaceous plant in Iran with small yellow flowers and several times pinnately divided leaves in worm shape. The plant was found to be cytotoxic in our previous studies.   Materials and Methods: A. talagonica was collected in May 2005 from Talegan in north of Iran during the full flowering stage. Dried aerial parts of the plant were r...

A well known anti-cancer lignan arctiin has not been studied for its antibacterial activity based on our literature search. In the present work, the antibacterial and general toxicity of the arctiin from the seeds of Centaurea sclerolepis is studied. Arctiin did not show any significant antibacterial activity against both Gram-positive and Gram-negative bacteria when compared with the positive ...

Marine algal community signifies a huge source of compound endowed with ingenious structure and potential biological activities. Cytotoxicity of plant or fungal material is considered as the presence of antitumor compounds. In this study, ethanol extracts of seaweeds Dictyota dichotoma var. velutricata, D. hauckiana, D. indica, Iyengaria stellata, Jolyna laminarioides, Melanothamnus afaqhusaini...

Methanolic extracts of 11 Rumex L. species (Polygonaceae) were examined against brine shrimp and R. scutatus L. has shown significant brine shrimp lethality (LC5O=0.96 |a,g/ml). Methanolic extracts of the roots of R. scutatus were fractionated and the active fraction led to the isolation of 4 anthraquinone aglycones: emodin, chrysophanol, physcion and aloe emodin. Their toxic sequence was found...

Background and objectives: Ferula gummosa Boiss. (Umbelliferae) is a popular medicinal plant, which is known mostly for therapeutic uses of its oleo-gum-resin (Barijeh in Persian). In the present study, the essential oil of F. gummosa roots was investigated for its phytochemical constituents, antioxidant activity and toxicity potential. Method...

The goal of the present work is to fabricate selenium nanoparticles utilising Morinda citrifolia leaves extract via green approach. UV-Vis spectroscopy, FT-IR, and TEM were used characterise nanoparticles. size generated SeNPs in was anticipated be 12-160 nm based on images. antioxidant activity NPs discovered 66.7 83.7% free radical inhibtion. When concentration rises, viability cancer cells d...

The methanol extract of Cassia fistula seeds was investigated for potential antimicrobial activity against medically important bacterial, yeast and fungal strains. The antimicrobial activity was determined in methanol extract using the disk diffusion technique and the broth dilution method. The extract was effective on tested microorganism and the minimum inhibitory concentration (MIC) values w...