background: breast cancer is the most common malignancy among women. it is estimated that 1 in 10 women worldwide is affected by breast cancer during their lifetime. in 5 to 10% of breast cancer patients, the disease results from a hereditary predisposition, which can be attributable to mutations in either of two tumor suppressor genes, brca1 and brca2 to a large extent. brca2 6174delt mutation...

The purpose of this study was to assess the detection rate of mammography in breast cancer and the attendance rate in response to the call for screening mammography in females before the development of symptoms. One-thousand four-hundred and thirty-eight women over 35 years of age who had no complaint and had normal breast examinations were called for mammography. Out of the 10,000 women u...

background: breast cancer is the most common type of cancer and is the second leading cause of cancer deaths in women. however, if detected in early stages, the disease is controllable. in view of the important role of women's beliefs and the necessity of performing screening behaviors in early detection of breast cancer, this study was carried out to determine the psycho-cognitive factors affe...

introduction: breast cancers in the early phase frequently undergo distant metastasis and survival of patients is greatly dependent on distant metastasis. the occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular invasion. the aim of this study was to examine the presence of keratin-19 mrn...

Background: Pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. Breast cancer is one of the most common cancers among women worldwide. Treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

Mammography remians the procedure of choice in screening asymptomatic women for breast cancer. However, in patients with symptoms, other types of imaging play an important role in the detection of malignancies. The high cost and lack of availability of PET and MRI largely precludes the use in this patient population. TI-201 is nbt the imaging agent of choice because of its wash-out and redistri...

breast cancer is characterized by a distinct metastatic pattern involving the regional lymph nodes, bone marrow, lung and liver. tumour cell migration and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. detection of breast cancer and its metastasis at the earliest stage is important for the management and prediction...

abstract objective: detection of p53 gene mutation on its codon 248 between iranian women with breast cancer by pcr-rflp. material and methods: dna extraction of tumor tissues was performed in 53 patients with primary breast cancer. designing primer for the sub-studying codon was performed with nti-vector software and detection of codon 248 mutation was done by msp i pcr_rflp. results: the soma...