Breast cancer is the most common cancer in women. Several risk factors such as age, family history of breast cancer, marital status, early menarche and late menopause are related to breast cancer. Obesity is also a main health problem associated with breast cancer incidence and subsequent mortality. Association between obesity and expansion of breast cancer may be due to excessive sex steroid h...

apoptosis could be a major mechanism of antitumor effect of tamoxifen. therefore this study is designed to characterize the kinetic behavior of tamoxifen-induced apoptosis in the estrogen receptor positive (er+) and negative (er-) cell lines, mcf-7 and mda-mb-468. frequency of cell death was examined by trypan blue and acridine orange staining. annexin v-fluorescein/pi was used in flow cytometr...

background: fine-needle aspiration of breast cancer often provides moderate cellular material that is representative of the tumors. these samples can be used not only for cytological diagnosis but also to obtain information on the prognosis and likely response to therapy by using immunohistochemical staining studies. methods: we assessed the degree of correlation between prognostic biologic mar...

objective(s): regarding the presence of many active biological constituents in avicennia marina, the present investigation was carried out to study cytotoxic activity of crude methanol leave extract and column chromatographic fractions of a. marina against mda-mb 231 cell line (human breast cancer cell) and hek (human embryonic kidney cell) line .   materials and methods: the anticancer activit...

Breast cancer has become common in developing and developed countries. Alarming increase in this disease as a leading cause of death in women is a concern of all. Despite the significant improvements in the management of breast cancer, the survival rate is not more than 20% - 25%. For this study, MDA-MB231 cell line was used and the effect of ICD-85 (biologically active peptides from venomous ...

a new series of anti-cancer agents based on 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline scaffold containing n,n-diethylamino ethoxy, piperidinyl ethoxy or morpholinyl ethoxy group at the para position of the c-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including mcf-7 (er positive breast cancer cell), mda-mb231 (er-ne...

Objective(s): Development of molecules that specifically recognize cancer cells is one of the major areas in cancer research. Human epidermal growth factor receptor 2 (HER2) is specifically expressed on the surface of breast cancer cells. HER2 is associated with an aggressive phenotype and poor prognosis. In this study we aimed to isolate RNA aptamers that specifically bind to HER2 overexpressi...

background: trace elements play an important role in a number of biological processes. astaxanthin (asx), a carotoid pigment found in certain marine plant and animals, has shown anti cancer and anti free radical properties. this work intended to understand the effect of astaxanthin in breast cancer (invasive ductal carcinoma, idc) by using micro-pixe method. for this aim the concentration of tr...