نتایج جستجو برای: brca2

تعداد نتایج: 4162  

Journal: :Human molecular genetics 2008
Xiaowei Chen Joellen Weaver Betsy A Bove Lisa A Vanderveer Susan C Weil Alexander Miron Mary B Daly Andrew K Godwin

The contribution of BRCA1 and BRCA2 to familial and non-familial forms of breast cancer has been difficult to accurately estimate because of the myriad of potential genetic and epigenetic mechanisms that can ultimately influence their expression and involvement in cellular activities. As one of these potential mechanisms, we investigated whether allelic imbalance (AI) of BRCA1 or BRCA2 expressi...

Journal: :Cancer research 2011
Hui-Feng Wang Katsuya Takenaka Akira Nakanishi Yoshio Miki

BRCA2 germline mutations account for the majority of heredity breast and ovarian cancer. Besides its role in DNA damage repair, BRCA2 also plays an important role in cytokinesis, transcription regulation, and cancer cell proliferation. Recently, we reported that BRCA2 localizes to centrosomes as well as nuclei and the dysfunction of BRCA2 in a centrosome causes abnormalities in cell division. H...

Journal: :Cancer research 1996
J P Vaughn F D Cirisano G Huper A Berchuck P A Futreal J R Marks J D Iglehart

Identifying the conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the function of the tumor suppressor gene. In this study, expression of BRCA2 mRNA is shown to be regulated by the cell cycle and associated with proliferation in normal and tumor-derived breast epithelial cells. Cells arrested in G(0) or early G1 contained low levels of BRCA2 mRNA. After r...

2017
Renea A Taylor Michael Fraser Julie Livingstone Shadrielle Melijah G Espiritu Heather Thorne Vincent Huang Winnie Lo Yu-Jia Shiah Takafumi N Yamaguchi Ania Sliwinski Sheri Horsburgh Alice Meng Lawrence E Heisler Nancy Yu Fouad Yousif Melissa Papargiris Mitchell G Lawrence Lee Timms Declan G Murphy Mark Frydenberg Julia F Hopkins Damien Bolton David Clouston John D McPherson Theodorus van der Kwast Paul C Boutros Gail P Risbridger Robert G Bristow

Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes and methylomes of localized PCa from 14 carriers of deleterious germline BRCA2 mutations (BRCA2-mutant PCa). We show that BRCA2-mutant PCa harbour increased g...

Journal: :Cancer research 2000
C S Sinclair R Berry D Schaid S N Thibodeau F J Couch

Epidemiological studies have suggested that the breast cancer susceptibility genes, BRCA1 and BRCA2, may be involved in the development of prostate cancer. Several studies have screened prostate cancer populations for the presence of BRCA1 and BRCA2 mutations, with few mutations identified. In this study, 22 high-risk prostate cancer families (at least three cases of prostate cancer) were scree...

Journal: :Science 2002
Haijuan Yang Philip D Jeffrey Julie Miller Elspeth Kinnucan Yutong Sun Nicolas H Thoma Ning Zheng Phang-Lang Chen Wen-Hwa Lee Nikola P Pavletich

Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucle...

Journal: :Current Biology 2009
Feng Zhang Jianglin Ma Jiaxue Wu Lin Ye Hong Cai Bing Xia Xiaochun Yu

BRCA1 and BRCA2 are often mutated in familial breast and ovarian cancer. Both tumor suppressors play key roles in the DNA-damage response. However, it remains unclear whether these two tumor suppressor function together in the same DNA-damage response pathway. Here, we show that BRCA1 associates with BRCA2 through PALB2/FANCN, a major binding partner of BRCA2. The interaction between BRCA1 and ...

Journal: :Cancer research 2002
Colleen S Sinclair Camilo Adem Ali Naderi Cheryl L Soderberg Michele Johnson Kangjian Wu Linda Wadum Vicki L Couch Thomas A Sellers Daniel Schaid Jeffrey Slezak Zach Fredericksen James N Ingle Lynn Hartmann Robert B Jenkins Fergus J Couch

The chromosome 17q23 region is frequently amplified in breast tumors. Gain of the region is present in 50% of BRCA1-associated breast tumors and 87% of BRCA2-associated breast tumors. The amplification frequency of the RPS6KB1 and TBX2 oncogenes from this amplicon was compared in 27 BRCA1 and BRCA2 mutant breast tumors, 15 breast tumors from high-risk patients with no BRCA1 or BRCA2 mutations, ...

Journal: :Cancer research 2008
Subha Philip Srividya Swaminathan Sergey G Kuznetsov Sreenivas Kanugula Kajal Biswas Suhwan Chang Natalia A Loktionova Diana C Haines Philipp Kaldis Anthony E Pegg Shyam K Sharan

Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRC...

Journal: :archives of breast cancer 0
lamia elfandi school of biological sciences, the libyan academy, tripoli, libya ghada said department of genetic engineering, biotechnology research center (btrc), twisha, tripoli, libya saleh suleiman saleh department of genetic engineering, biotechnology research center (btrc), twisha, tripoli, libya mohamed marwan faculty of sciences, tripoli university, tripoli, libya nabil enattah department of genetic engineering, biotechnology research center (btrc), twisha, tripoli, libya

background: breast cancer is the most common malignancy among women. it is estimated that 1 in 10 women worldwide is affected by breast cancer during their lifetime. in 5 to 10% of breast cancer patients, the disease results from a hereditary predisposition, which can be attributable to mutations in either of two tumor suppressor genes, brca1 and brca2 to a large extent. brca2 6174delt mutation...

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