We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A ro...

BACKGROUND AND PURPOSE The relationship between blood pressure (BP) and heart rate (HR) and MRI assessments of subcortical T2 hyperintensities was evaluated in healthy elderly men and women. METHODS Casual and 24-hour ambulatory BPs and HR measurements were taken of 144 elderly individuals, aged 55 to 79 years. Subjects had no evidence of previous health disorders. MRI scans of white matter, ...

The mechanisms by which aging and other processes can affect the structure and function of brain networks are important to understanding normal age-related cognitive decline. Advancing age is known to be associated with various disease processes, including clinically asymptomatic vascular and inflammation processes that contribute to white matter structural alteration and potential injury. The ...

OBJECTIVE Cerebral small vessel disease is the most common cause of vascular cognitive impairment and typically manifests with slowed processing speed. We investigated the impact of lesion location on processing speed in age-related small vessel disease. METHODS A total of 584 community-dwelling elderly underwent brain MRI followed by segmentation of white matter hyperintensities. Processing ...

BACKGROUND AND PURPOSE Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited. METHODS T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensitie...

BACKGROUND CADASIL is responsible for diffuse hyperintensities in the white matter on FLAIR images. These lesions are often associated with focal lesions in the basal ganglia such as lacunar infarctions. The prevalence and significance of diffuse or confluent thalamic hyperintensities (CTH) remain unknown. METHODS The frequency of hyperintensities on FLAIR images in the thalamus was assessed ...

frequent finding in magnetic resonance imaging (MRI) studies evaluating individuals with bipolar disorder compared with healthy controls. Such findings have been reported in individuals with the early stages of bipolar disorder as well as in their unaffected relatives, and this has been taken as suggestive that white-matter hyperintensities could reflect abnormal neurodevelopmental processes in...

BACKGROUND AND PURPOSE Cerebellar atrophy and white matter T2-hyperintensities have been characterized as cerebellar lesions of multiple system atrophy (MSA). The aim of the study was to correlate MR images with histologic findings in cerebellar lesions of MSA. MATERIALS AND METHODS Postmortem T2-weighted images using 1.5T were compared with histologic findings in 7 postmortem-proved cases wi...