Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

I read with great interest the article by Hilario et al. The authors retrospectively analyzed the MR imaging data from the first 30 days after injury in 108 patients with severe head trauma and found that the presence of posterior and bilateral brain stem injuries were poor prognostic signs. Although they analyzed the location of the brain stem lesions, they did not analyze the volume or depth ...

AIMS Glioblastoma is the most frequent and malignant brain tumor. Recurrence is inevitable and most likely connected to tumor invasion and presence of therapy resistant stem-like tumor cells. The aim was therefore to establish and characterize a three-dimensional in vivo-like in vitro model taking invasion and tumor stemness into account. METHODS Glioblastoma stem cell-like containing spheroi...

A 68-year-old man presented with a highly symptomatic brain stem tumor originally thought to be a brain stem glioma. Intraoperative MR imaging guidance was used to resect the tumor, and real-time evoked potentials improved during surgery. Pathology findings unexpectedly indicated that the tumor was an intra-axial brain stem schwannoma, a condition reported, to our knowledge, only 6 times previo...

Introduction: Psychotropic drugs exert their effects, in part, by increasing neurotrophin levels in the brain. Nerve growth factor (NGF) protein levels after treatment with only a limited number of psychotropics have been determined. The present study was designed in order to evaluate the effects of acute and chronic administration of different psychotropic drugs on NGF protein levels in fiv...

After traumatic brain injury (TBI), subcortical white matter damage may induce a functional disconnection leading to a dissociation of regional cerebral metabolic rate of glucose (CMRglc) between the cerebral cortex and deeper brain regions. Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with depth of coma after TBI. Methods: Eleven adult h...

objective(s): the stimulation of neural stem cells (nscs) differentiation into neurons has attracted great attention in management of neurodegenerative disease and traumatic brain injury. it has been reported that selegiline could enhance the morphologic differentiation of embryonic stem cells. therefore this study aimed to investigate the effects of selegiline on nscs differentiation with focu...

objective(s) clinical studies of treating traumatic brain injury (tbi) with autologous adult stem cells led us to examine the impression of a combination therapy. this was performed by intravenous injection of human umbilical cord matrix stem cell (hucmsc-wharton,s jelly stem cell) with bone marrow cell mobilized by granulocytecolony stimulating factor (g-csf) in rats injured with cortical comp...