introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

Epilepsy is a disorder categorized by recurrent seizures and leads to changes in neuronal death and neurogenesis. Recently the search for new targets in the therapy of epilepsy has focused on brain inflammation because brain inflammation and the associate blood brain barrier damage appears to be basic part of epilepsy pathophysiology-erythropoietin (EPO) regulates biological processes counting ...

Stem cell transplantation therapy may inhibit inflammation during stroke and increase the presence of healthy cells in brain. The novelty this work, is to introduce a new mathematical model stem transplanted treat stroke. This manuscript studies stability by using current biological information on as possible treatment for from microglia proposed represent dynamics various immune brain (resting...

In the process of neuronal inflammation, an increased in inflammatory cytokines (IL-1β, IL-6 and TNF-α) from immune cells (leukocytes and macrophages), brain cells (microglia, astrocytes and neurons) and in hippocampus, amygdala occurs. Raise the level of cytokines result in reduced in production of molecules that are related to plasticity, especially BDNF, IGF-1 and VEGF. Microglia ...

It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including chronic inflammatory liver diseases, are associated with changes in central neural transmission that result in alterations in behavior. These behavioral changes include sickness behaviors, such as fatigue, cognitive dysfunction, mood disorders, and sleep disturbances. While such behaviors have a ...

The review covers current concepts on cell and molecular mechanisms of neuroinflammation and aging with the special focus on the regulation of cytokine-producing activity of astroglial cells and intercellular communication. The review reflects that a key component of the aging phenomenon as a result of ineffective implementation of anti-inflammatory response are processes of the dysregulated cy...

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Home / Archives Vol. 8 No. 2 (2022): July Research Article THE COMBINATION OF HIGH FAT DIET AND MONOSODIUM GLUTAMATE ALTERING ADIPOGENESIS, BRAIN RESISTIN SERUM CORTISOL LEVEL IN FEMALE RAT Authors Aris Widayati Department of Physiology, Faculty Medicine, Universitas Brawijaya, Malang, Indonesia Dewi Mustika Yhusi Karina Riskawati Agustin Iskandar Parasitology, Nia Kurnianingsih DOI: https://do...

During the last decade, experimental research has demonstrated a prominent role of glial cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and recurrence. In particular, alterations in the phenotype and function of activated astrocytes and microglial cells have been described in experimental and human epileptic tissue, including modifications in potassium...

Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...