X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been demonstrated that the doublecortin gene is implicated in this disorder. In order to study the function of Doublecortin, we analyzed the protein upon transfection of COS cells. Doublecortin was found to bind to the microtubule cytoskeleton. In vitro assays (using biochemical methods, DIC microscopy and el...

INTRODUCTION Functional MR imaging is increasingly being used for presurgical language assessment in the treatment of patients with brain tumors, epilepsy, vascular malformations, and other conditions. The inherent complexity of fMRI, which includes numerous processing steps and selective analyses, is compounded by institution-unique approaches to patient training, paradigm choice, and an eclec...

Encapsulated intracerebral haematoma (EICH)is an interesting and rare entity. In this paper; a chronic encapsulated intracerebral haematoma without vascular malformation is reported. Although the clinical course and radiological appearances suggested a brain tumour histopathological examination demonstrated a cap-

Despite the initial promises, less invasive autopsy by postmortem MRI has not gained widespread acceptance and is not yet used as a clinical tool. Current evidence on postmortem MRI is primarily limited to examination of fetal brain malformations. Large prospective studies funded by the UK Department of Health evaluating accuracy of postmortem MRI are now nearing completion. Less invasive autop...

Purpose: To seek adequate sequence of MR angiography (MRA) on developmental venous anomaly in the brain. Material and Methods: We collected ten cases who demonstrated developmental venous anomaly on MR image. Eight patients among them, both 3D timeof-flight (TOF) with or without Gadolinium-DTPA enhancement and phase contrast(PC) were performed: TOF without enhancement in five, TOFwith enhanceme...

In general, language comprehension is surprisingly reliable. Listeners very rapidly extract meaning from the unfolding speech signal, on a word-by-word basis, and usually successfully. Research on 'semantic illusions' however suggests that under certain conditions, people fail to notice that the linguistic input simply doesn't make sense. In the current event-related brain potentials (ERP) stud...

congenital malformation (cm) will begin to emerge as one of the major childhood health problems .treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. the aim of this study was to determine frequency of cm in yazd central city of the islamic republic of iran to find out if there has been any difference in the rate and type...

Recent advances in genetics and neuroimaging have greatly contributed to our understanding of the spectrum of midline brain and craniofacial malformations known as holoprosencephaly. Neuroradiologic studies have provided detailed characteristics of four major types of holoprosencephaly: alobar, semilobar, lobar, and middle interhemispheric variant. Clinical studies in children with these types ...