Protective effects of boswellic acid (BA) against acetaminophen (APAP)-induced hepatotoxicity in Balb/ cA mice were examined. BA, at 0.05 or 0.1%, was supplied for 4 weeks. Acute liver injury was induced by APAP treatment. Results showed that BA intake increased hepatic BA bioavailability. APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glu...

Boswellia serrata and Boswellia sacra (syn. B. carteri) are important medicinal plants widely used for their content of bioactive lipophilic triterpenes. The qualitative and quantitative determination of boswellic acids (BAs) is important for their use in dietary supplements aimed to provide a support for osteoarthritic and inflammatory diseases. We used High Performance Liquid Chromatography (...

The petroleum ether extract of the oleo-gum-resin of Boswellia carteri Bird., the chloroformic successive extract of the oleo-gum-resin of Commiphora myrrha Engl. as well as the prepared volatile contents from both resins showed significant anti-inflammatory activity in carragennan-induced edema in rats. Phytochemical investigation of the volatile fractions was carried out using GC/MS and revea...

Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell surv...

Vascular remodeling is an important complication of hypertension with oxidative stress-related profibrotic pathways involved. The transforming growth factor β1 (TGF-β1) has been shown to be a potential target of vasoprotection, and has multiple roles in vascular remodeling. Acetyl-11-Keto-β-Boswellic Acid (AKBA) is one of the active principles of Boswellic acids, and shows antioxidant activity ...

ABSTRACT Objective: To evaluate the effectiveness of complementary therapies in management symptom clusters children and adolescents with cancer undergoing palliative care. Method: Systematic review guided by Preferred Reporting Items for Reviews Meta-Analyses, resorting to databases MEDLINE, Web Science, Central Cochrane, PsycINFO. The identification, selection, inclusion, extraction, methodol...

Intervention in Obesity & Diabetes 11-Keto-β-Boswellic Acid and 5-Chloro-8-Hydroxyquinoline Attenuate Renal Damage Streptozotocin-Induced Diabetic Mice Ghulam Abbas1,2*, Sulaiman Al-Hashmi2*, Ahmed Al-Harrasi2*, René Csuk3, Issa Al-Amri1,4, Najeeb Ur Rehman2, Al-Adawi1 Samera Khalaf4 1Department of Biological Sciences Chemistry, University Nizwa, Sultanate Oman, Oman 2Natural Medical Research C...