A multi-functional mesoporous silica nanoparticle (MSN)-based boron neutron capture therapy (BNCT) agent, designated as T-Gal-B-Cy3@MSN, was synthesized with hydrophobic mesopores for incorporating a large amount of o-carborane (almost 60% (w/w) boron atoms per MSN), and the amines on the external surface were conjugated with trivalent galactosyl ligands and fluorescent dyes for cell targeting ...

Boron neutron capture therapy (BNCT) is a radiotherapy that has mainly been used to treat malignant brain tumours, melanomas, and head and neck cancer. In BNCT, the patient receives an intravenous infusion of a B carrier, which accumulates in the tumour area. The tumour is irradiated with epithermal or thermal neutrons, which result in a boron neutron capture reaction B(n,α)Li. This generates h...

Preclinical studies for boron neutron capture therapy (BNCT) using epithermal neutrons are ongoing at several laboratories. The absorbed dose in tumor cells is a function of the thermal neutron flux at depth, the microscopic boron concentration, and the size of the cell. Dosimetry is therefore complicated by the admixture of thermal, epithermal, and fast neutrons, plus gamma rays, and the array...

Boron neutron capture therapy (BNCT) is a radiation treatment for cancer that uses charged particles from the B(n, α) Li reaction. The dose from the resulting alpha particles and Li nuclei is called the boron dose, and is the primary dose delivered to tumor cells. Dose to the tumor and surrounding cells during neutron beam irradiation comes not only from the boron dose, but also from dose resul...

background: boron neutron capture therapy (bnct) is a very promising treatment for patients suffering gliobastoma multiforme, an aggressive type of brain cancer, where conventional radiation therapies fail. thermal neutrons are suitable for the direct treatment of cancers which are located at near-tissue-surface deep-seated tumors need harder, epithermal neutron energy spectra. materials and me...

This study was performed to investigate the biological effects of boron neutron capture therapy (BNCT) on the testes and eyes in mice using HANARO Nuclear Reactor, Korea Atomic Energy Research Institute. BNCT relies on the high capacity of 10B in capturing thermal neutrons. Sodium borocaptate (BSH, 75 ppm, iv) and boronophenylalanine (BPA, 750 ppm, ip) have been used as the boron delivery agent...

Background: Boron Neutron Capture Therapy (BNCT) is a very promising treatment for patients suffering gliobastoma multiforme, an aggressive type of brain cancer, where conventional radiation therapies fail. Thermal neutrons are suitable for the direct treatment of cancers which are located at near-tissue-surface deep-seated tumors need harder, epithermal neutron energy spectra. Materials and Me...

Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy tissue. However, BNCT in practice is still limited due to the lack of boron-containing compounds that selective...

Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intens...

The treatment of malignant brain tumors using conventional therapies and surgery often leads to tumor recurrence and/or unwanted side effects. Boron neutron capture therapy (BNCT) is a binary and localized form of treatment for brain tumors and other difficult-to-treat cancers that uses nontoxic boron-containing agents. Boronated porphyrins and derivatives constitute a class of highly promising...